Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies.
Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies.
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DOI：
10.1016/j.nicl.2015.01.017
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发表时间：
2015
影响因子：
4.2
通讯作者：
OBrien, John T.
中科院分区：
文献类型：
--
作者：
Mak, Elijah;Su, Li;Williams, Guy B.;Watson, Rosie;Firbank, Michael;Blamire, Andrew M.;OBrien, John T.
从连续MRI扫描测量的全脑体积变化百分比（PBVC）被广泛接受为阿尔茨海默病（AD）疾病进展的敏感标志物。然而，PBVC在痴呆鉴别诊断中的实用性仍有待建立。我们比较了AD和路易体痴呆（DLB）的PBVC，并调查了与临床指标的相关性。72名受试者（14名DLB、25名AD和33名健康对照（HC））在基线时接受了临床评估和3次Tesla T1加权MRI，并在12个月时重复。我们使用FSL-SIENA来估计每个受试者的PBVC。体素分析和ANCOVA比较了DLB和AD之间的PBVC，而相关性检验则检查了PBVC与临床指标的相关性。在包括脑室周围区域在内的大脑广泛区域中，AD在1年内的萎缩（1.8%）显著大于DLB（1.0%; p = 0.01）和HC（0.9%; p < 0.01）。DLB和HC之间的PBVC无显著差异（p = 0.95）。DLB和AD之间的认知下降没有差异。在合并痴呆组（AD和DLB）中，年龄越小，萎缩率越高（r = 0.49，p < 0.01）。与DLB相比，AD显示出更快的整体脑萎缩率，DLB与HC具有相似的萎缩率。在痴呆症受试者中，年龄较小与加速萎缩有关，反映了年轻人的更具侵略性的疾病。PBVC可以帮助区分DLB和AD，但其作为DLB结果标志物的效用有限。与DLB相比，AD显示出更快的全局和局部脑萎缩。在DLB和HC中发现了相似的全局和区域萎缩率。纵向影像学检查可提高DLB与AD的鉴别诊断价值。萎缩率可能不是跟踪DLB疾病进展的有用标志物。
Percent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer's disease (AD). However, the utility of PBVC in the differential diagnosis of dementia remains to be established. We compared PBVC in AD and dementia with Lewy bodies (DLB), and investigated associations with clinical measures. 72 participants (14 DLBs, 25 ADs, and 33 healthy controls (HCs)) underwent clinical assessment and 3 Tesla T1-weighted MRI at baseline and repeated at 12 months. We used FSL-SIENA to estimate PBVC for each subject. Voxelwise analyses and ANCOVA compared PBVC between DLB and AD, while correlational tests examined associations of PBVC with clinical measures. AD had significantly greater atrophy over 1 year (1.8%) compared to DLB (1.0%; p = 0.01) and HC (0.9%; p < 0.01) in widespread regions of the brain including periventricular areas. PBVC was not significantly different between DLB and HC (p = 0.95). There were no differences in cognitive decline between DLB and AD. In the combined dementia group (AD and DLB), younger age was associated with higher atrophy rates (r = 0.49, p < 0.01). AD showed a faster rate of global brain atrophy compared to DLB, which had similar rates of atrophy to HC. Among dementia subjects, younger age was associated with accelerated atrophy, reflecting more aggressive disease in younger people. PBVC could aid in differentiating between DLB and AD, however its utility as an outcome marker in DLB is limited. AD showed faster global and regional brain atrophy in comparison to DLB. Similar rates of global and regional atrophy were found in DLB and HC. Longitudinal imaging could improve clinical differentiation of DLB from AD. Atrophy rates might not be a useful marker to track disease progression in DLB.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
6
作者：
Nelson PT;Schmitt FA;Jicha GA;Kryscio RJ;Abner EL;Smith CD;Van Eldik LJ;Markesbery WR
通讯作者：
Markesbery WR
影响因子：
168.9
作者：
Fox, NC;Crum, WR;Rossor, MN
通讯作者：
Rossor, MN
影响因子：
2.6
作者：
Marshall, Gad A.;Fairbanks, Lynn A.;Cummings, Jeffrey L.
通讯作者：
Cummings, Jeffrey L.