Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis.
Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis.
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DOI：
10.3389/fcvm.2023.1155916
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发表时间：
2023
影响因子：
3.6
通讯作者：
Baradaran, Hediyeh
中科院分区：
文献类型：
--
作者：
Culleton, Sinead;Niu, Mary;Alexander, Matthew;McNally, J. Scott;Yuan, Chun;Parker, Dennis;Baradaran, Hediyeh
关键词：
颈动脉粥样硬化斑块是脑卒中的重要独立危险因素。载脂蛋白 E (APOE) 影响胆固醇水平，某些异构体与颈动脉粥样硬化增加相关，但 APOE 和颈动脉斑块之间的确切关联尚不确定。该研究旨在评估 APOE 与颈动脉斑块之间的关联。我们进行了系统回顾以检索所有检查颈动脉斑块与 APOE 之间关联的研究。本研究是根据 PRISMA 指南进行的。独立读者从每项研究中提取相关数据，包括影像评估类型、斑块定义、APOE E4 携带者状态频率和基因分型类型。对研究异质性和发表偏倚进行了荟萃分析评估。结果以森林图形式呈现，并使用随机效应模型进行总结。筛选 838 项研究后，纳入 17 项研究进行系统评价。对 5 项已发表研究的荟萃分析显示，ε4 纯合性与颈动脉斑块之间存在显着相关性 [比值比 (OR)，1.53；比值比 (OR)，1.53； 95% CI，1.16，2.02； p = .003]。此外，拥有至少一个ε4等位基因、杂合子或纯合子的患者与颈动脉斑块之间存在显着相关性（OR，1.25；95% CI，1.03，1.52；p = .03）。最后，ε4 杂合性和颈动脉斑块之间没有关联（OR，1.08；95% CI，0.93，1.26；p = .30）。 APOE ε4 等位基因与颅外颈动脉粥样硬化斑块显着相关，特别是对于纯合个体。
Carotid atherosclerotic plaque is an important independent risk factor for stroke. Apolipoprotein E (APOE) influences cholesterol levels and certain isoforms are associated with increased carotid atherosclerosis, though the exact association between APOE and carotid plaque is uncertain. The study aimed to evaluate the association between APOE and carotid plaque. A systematic review was performed to retrieve all studies which examined the association between carotid plaque and APOE. This study was conducted in accordance with the PRISMA guidelines. Independent readers extracted the relevant data from each study including the type of imaging assessment, plaque definition, frequency of APOE E4 carrier status and type of genotyping. Meta-analyses with an assessment of study heterogeneity and publication bias were performed. Results were presented in a forest plot and summarized using a random-effects model. After screening 838 studies, 17 studies were included for systematic review. A meta-analysis of 5 published studies showed a significant association between ε4 homozygosity and carotid plaque [odds ratio (OR), 1.53; 95% CI, 1.16, 2.02; p = .003]. Additionally, there was a significant association between patients possessing at least one ε4 allele, heterozygotes or homozygotes, and carotid plaque (OR, 1.25; 95% CI, 1.03, 1.52; p = .03). Lastly, there was no association between ε4 heterozygosity and carotid plaque (OR, 1.08; 95% CI, 0.93, 1.26; p = .30). APOE ε4 allele is significantly associated with extracranial carotid atherosclerotic plaque, especially for homozygous individuals.
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影响因子：
2.1
作者：
Kahraman, S;Kiykim, AA;Çaglar, S
通讯作者：
Çaglar, S
影响因子：
8.3
作者：
Debett, Stephanie;Lambert, Jean-Charles;Zureik, Mahmoud
通讯作者：
Zureik, Mahmoud
影响因子：
8.3
作者：
Djoussé, L;Myers, RH;Ellison, RC
通讯作者：
Ellison, RC
影响因子：
3.8
作者：
Hsieh, Yi-Chen;Hsieh, Fang-I;Chen, Chien-Jen
通讯作者：
Chen, Chien-Jen
影响因子：
8.3
作者：
Beilby, JP;Hunt, CCJ;Hung, J
通讯作者：
Hung, J