Calibration of a Heterogeneous Brain Model Using a Subject-Specific Inverse Finite Element Approach.
Calibration of a Heterogeneous Brain Model Using a Subject-Specific Inverse Finite Element Approach.
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使用受试者特异性的逆有限元方法对异质大脑模型进行校准。
DOI：
10.3389/fbioe.2021.664268
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发表时间：
2021
影响因子：
5.7
通讯作者：
Panzer MB
中科院分区：
文献类型：
--
作者：
Giudice JS;Alshareef A;Wu T;Knutsen AK;Hiscox LV;Johnson CL;Panzer MB
人脑的有限元(FE)模型是研究创伤性脑损伤(TBI)生物力学和评估头部撞击损伤风险的核心。然而，许多现有的FE人脑模型都是用简化的脑实质表示法建立的，这可能会限制它们作为损伤预测工具的适用性。神经成像技术和脑生物力学的最新进展为提高FE脑模型的生物逼真度提供了新的和必要的实验数据。在这项研究中，开发了CAB-20MSym模板模型，并进行了校准和广泛的验证。为了实现材料的异质性，利用磁共振弹性成像(MRE)模板图像来定义大脑模型的相对刚度梯度。通过最小化模型预测的脑位移和实验位移数据之间的误差，使用多阶段逆有限元(IFE)方法来校准材料参数，这些参数定义了潜在的非线性偏差响应。这一过程包括使用低严重性、低变形的撞击情况来校准材料的无限小剪切模数，以及使用高严重性、高变形的情况来校准材料的非线性，这些情况来自于从身体标本获得的原位脑移位数据集。为了减少IFE校准中使用的有限元模型与获得实验数据的身体标本之间的几何差异，开发了这些身体脑标本的特定对象模型，并将其用于校准过程。最后，使用33个旋转头部撞击的独立脑移位数据广泛验证了校准的材料参数，这些数据跨越多个加载方向(矢状、冠状、轴向)、大小(20-40 rad/S)、持续时间(30-60 ms)和严重程度。总体而言，异质CAB-20MSym模板模型显示出良好的生物保真度，与原位脑移位数据相比，平均总体CORA评分为0.63±0.06。在人类志愿者(N=6)的非损伤性旋转撞击下，由校准模型预测的应变也显示出与标记磁共振成像研究获得的活体测量相似的生物保真度。除了作为进一步研究脑损伤生物力学的解剖学准确模型外，基于MRE的实现材料异质性的框架还可以作为在未来模型中纳入特定于对象的材料属性的基础。
Central to the investigation of the biomechanics of traumatic brain injury (TBI) and the assessment of injury risk from head impact are finite element (FE) models of the human brain. However, many existing FE human brain models have been developed with simplified representations of the parenchyma, which may limit their applicability as an injury prediction tool. Recent advances in neuroimaging techniques and brain biomechanics provide new and necessary experimental data that can improve the biofidelity of FE brain models. In this study, the CAB-20MSym template model was developed, calibrated, and extensively verified. To implement material heterogeneity, a magnetic resonance elastography (MRE) template image was leveraged to define the relative stiffness gradient of the brain model. A multi-stage inverse FE (iFE) approach was used to calibrate the material parameters that defined the underlying non-linear deviatoric response by minimizing the error between model-predicted brain displacements and experimental displacement data. This process involved calibrating the infinitesimal shear modulus of the material using low-severity, low-deformation impact cases and the material non-linearity using high-severity, high-deformation cases from a dataset of in situ brain displacements obtained from cadaveric specimens. To minimize the geometric discrepancy between the FE models used in the iFE calibration and the cadaveric specimens from which the experimental data were obtained, subject-specific models of these cadaveric brain specimens were developed and used in the calibration process. Finally, the calibrated material parameters were extensively verified using independent brain displacement data from 33 rotational head impacts, spanning multiple loading directions (sagittal, coronal, axial), magnitudes (20–40 rad/s), durations (30–60 ms), and severity. Overall, the heterogeneous CAB-20MSym template model demonstrated good biofidelity with a mean overall CORA score of 0.63 ± 0.06 when compared to in situ brain displacement data. Strains predicted by the calibrated model under non-injurious rotational impacts in human volunteers (N = 6) also demonstrated similar biofidelity compared to in vivo measurements obtained from tagged magnetic resonance imaging studies. In addition to serving as an anatomically accurate model for further investigations of TBI biomechanics, the MRE-based framework for implementing material heterogeneity could serve as a foundation for incorporating subject-specific material properties in future models.
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影响因子：
2.2
作者：
Darvish, KK;Crandall, JR
通讯作者：
Crandall, JR
影响因子：
2.4
作者：
FALLENSTEIN, GT;HULCE, VD;MELVIN, JW
通讯作者：
MELVIN, JW
影响因子：
3.8
作者：
Gabler, Lee F.;Crandall, Jeff R.;Panzer, Matthew B.
通讯作者：
Panzer, Matthew B.
影响因子：
2.4
作者：
Arbogast, KB;Margulies, SS
通讯作者：
Margulies, SS
DOI：
10.1016/j.jmbbm.2015.02.024
发表时间：
2015-06
影响因子：
3.9
作者：
Budday, Silvia;Nay, Richard;de Rooij, Rijk;Steinmann, Paul;Wyrobek, Thomas;Ovaert, Timothy C.;Kuhl, Ellen
通讯作者：
Kuhl, Ellen