PRDM1/Blimp-1 controls effector cytokine production in human NK cells.
PRDM1/Blimp-1 controls effector cytokine production in human NK cells.
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DOI：
10.4049/jimmunol.1001682
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发表时间：
2010-11-15
期刊：
影响因子：
--
通讯作者：
Wright KL
中科院分区：
文献类型：
--
作者：
Smith MA;Maurin M;Cho HI;Becknell B;Freud AG;Yu J;Wei S;Djeu J;Celis E;Caligiuri MA;Wright KL
NK cells are major effectors of the innate immune response through cytolysis and bridge to the adaptive immune response through cytokine release. The mediators of activation are well studied however little is known about the mechanisms which restrain activation. In this report, we demonstrate that the transcriptional repressor PRDM1 (also known as Blimp-1 or PRDI-BF1) is a critical negative regulator of NK function. Three distinct PRDM1 isoforms are selectively induced in the CD56dim NK population in response to activation. PRDM1 coordinately suppresses release of IFNγ, TNFα and TNFβ through direct binding to multiple conserved regulatory regions. Ablation of PRDM1 expression leads to enhanced production of IFNγ and TNFα but does not alter cytotoxicity, while overexpression blocks cytokine production. Novel PRDM1 response elements are defined at both the IFNG and TNF loci. Collectively, these data demonstrate a key role for PRDM1 in the negative regulation of NK activation and position PRDM1 as a common regulator of both the adaptive and innate immune response.
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影响因子：
4.4
作者：
Dybkaer K;Iqbal J;Zhou G;Geng H;Xiao L;Schmitz A;d'Amore F;Chan WC
通讯作者：
Chan WC
在人类天然杀伤细胞中，活化T细胞NFATP和NFATC的核因子的激活和表达：CD16配体结合时调节。
DOI：
10.1084/jem.182.3.801
发表时间：
1995-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Aramburu J;Azzoni L;Rao A;Perussia B
通讯作者：
Perussia B
影响因子：
32.4
作者：
Kallies, Axel;Xin, Annie;Nutt, Stephen L.
通讯作者：
Nutt, Stephen L.
影响因子：
20.3
作者：
Mavropoulos, A;Sully, G;Clark, AR
通讯作者：
Clark, AR
影响因子：
20.3
作者：
Fehniger, TA;Cooper, MA;Caligiuri, MA
通讯作者：
Caligiuri, MA