Patterns of MHC‐dependent mate selection in humans and nonhuman primates: a meta‐analysis

Patterns of MHC‐dependent mate selection in humans and nonhuman primates: a meta‐analysis
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人类和非人灵长类动物 MHC 依赖性择偶模式:荟萃分析

DOI:
10.1111/mec.13920
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发表时间:
2017
期刊:
影响因子:
4.9
通讯作者:
L. Garamszegi
L. Garamszegi
中科院分区:
生物学1区
文献类型:
--
作者:
Jamie Winternitz;Jessica L. Abbate;Jessica L. Abbate;Elise Huchard;Jan Havlíček;L. Garamszegi

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脊椎动物的主要组织相容性复合体(MHC)基因是有效的适应性免疫反应的组成部分,并与性选择有关。来自一系列脊椎动物的证据支持基于MHC的对不同和不同交配伴侣的偏好,但来自人类配偶选择研究的证据是不同的和有争议的。人类研究特有的方法和取样特点使人很难知道人类群体之间结果的巨大差异是真实的还是人为的。为了更好地了解哪些过程可能影响人类和非人灵长类动物的MHC介导的配偶选择,我们使用来自7个灵长类物种的30项研究的58个效应量进行了遗传学控制的Meta分析。灵长类动物显示出有利于更多MHC多样性配偶的一般趋势,这对人类具有统计学意义。相比之下,没有MHC不相似配偶选择的趋势,对于人类,我们观察到的效应量表明选择了MHC不相似和MHC相似的配偶。仅关注MHC相似效应量,我们发现证据表明,对MHC相似性的偏好是观察性研究中人群种族异质性的人为因素,但在对社会文化偏见有更多控制的实验研究中并非如此。这表明,人类选择性交配偏见可能是某些基于MHC的配偶选择模式的原因。此外,灵长类动物基于MHC的交配偏好的总体效应量相对较弱(相异性的Fisher Z相关系数Zr = 0.044,多样性Zr = 0.153),需要在未来的研究中仔细设计抽样。总的来说,我们的研究结果表明,对MHC多样性伴侣的偏好对人类来说是重要的,并且可能在灵长类动物中保守。
Genes of the major histocompatibility complex (MHC) in vertebrates are integral for effective adaptive immune response and are associated with sexual selection. Evidence from a range of vertebrates supports MHC‐based preference for diverse and dissimilar mating partners, but evidence from human mate choice studies has been disparate and controversial. Methodologies and sampling peculiarities specific to human studies make it difficult to know whether wide discrepancies in results among human populations are real or artefact. To better understand what processes may affect MHC‐mediated mate choice across humans and nonhuman primates, we performed phylogenetically controlled meta‐analyses using 58 effect sizes from 30 studies across seven primate species. Primates showed a general trend favouring more MHC‐diverse mates, which was statistically significant for humans. In contrast, there was no tendency for MHC‐dissimilar mate choice, and for humans, we observed effect sizes indicating selection of both MHC‐dissimilar and MHC‐similar mates. Focusing on MHC‐similar effect sizes only, we found evidence that preference for MHC similarity was an artefact of population ethnic heterogeneity in observational studies but not among experimental studies with more control over sociocultural biases. This suggests that human assortative mating biases may be responsible for some patterns of MHC‐based mate choice. Additionally, the overall effect sizes of primate MHC‐based mating preferences are relatively weak (Fisher's Z correlation coefficient for dissimilarity Zr = 0.044, diversity Zr = 0.153), calling for careful sampling design in future studies. Overall, our results indicate that preference for more MHC‐diverse mates is significant for humans and likely conserved across primates.
批判性评论:主要组织相容性复合体和其他基因的基因型多态性的感官知觉:一些生理和系统发育的影响。
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DOI: 10.1093/genetics/132.2.575
发表时间: 1992
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发表时间: 1988
期刊: American journal of reproductive immunology and microbiology : AJRIM
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