Alarming dendritic cells for Th2 induction.

Alarming dendritic cells for Th2 induction.
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令人震惊的树突状细胞以进行Th2诱导。

DOI:
10.1084/jem.20072665
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发表时间:
2008-01-21
影响因子:
15.3
通讯作者:
Maizels, Rick M.
Maizels, Rick M.
中科院分区:
医学1区
文献类型:
--
作者:
MacDonald, Andrew S.;Maizels, Rick M.

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人们对细菌、病毒和原生动物等病原体激活树突状细胞 (DC) 驱动 1 型辅助 T (Th1) 反应的机制有了越来越多的了解,但我们对这些细胞如何引发 Th2 反应知之甚少。我们知识上的这种差距使我们在设计某些免疫介导疾病的治疗方法时处于明显的劣势。然而,在鉴定可增强 DC 诱导 Th2 的新型内源组织因子方面正在取得进展。
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
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