Nanoparticles for generating antigen-specific T cells for immunotherapy.
Nanoparticles for generating antigen-specific T cells for immunotherapy.
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DOI：
10.1016/j.smim.2021.101541
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发表时间：
2021-08
影响因子：
7.8
通讯作者：
Schneck JP
中科院分区：
文献类型：
--
作者：
Est-Witte SE;Livingston NK;Omotoso MO;Green JJ;Schneck JP
T细胞疗法在免疫刺激和免疫抑制应用中显示出作为免疫疗法的前景。然而，目前临床上基于T细胞的治疗形式，如过继细胞转移和疫苗，受到成本、治疗时间和患者变异性的限制。纳米颗粒提供了一个模块化的通用平台，以提高各种T细胞疗法的疗效，因为纳米颗粒的性质可以很容易地进行修改，以增强细胞靶向，器官靶向和细胞内化。纳米颗粒可以在产生抗原特异性T细胞应答的每个步骤中增强甚至取代内源性细胞-从抗原呈递和T细胞活化到T细胞维持。在这篇综述中，我们讨论了纳米颗粒在抗原特异性T细胞治疗中的独特应用，重点是纳米颗粒作为疫苗（激活内源性抗原呈递细胞（APC）），作为人工抗原呈递细胞（aAPC，直接激活T细胞），以及作为药物递送载体（支持激活的T细胞）。
T cell therapy shows promise as an immunotherapy in both immunostimulatory and immunosuppressive applications. However, the forms of T cell-based therapy that are currently in the clinic, such as adoptive cell transfer and vaccines, are limited by cost, time-to-treatment, and patient variability. Nanoparticles offer a modular, universal platform to improve the efficacy of various T cell therapies as nanoparticle properties can be easily modified for enhanced cell targeting, organ targeting, and cell internalization. Nanoparticles can enhance or even replace endogenous cells during each step of generating an antigen-specific T cell response – from antigen presentation and T cell activation to T cell maintenance. In this review, we discuss the unique applications of nanoparticles for antigen-specific T cell therapy, focusing on nanoparticles as vaccines (to activate endogenous antigen presenting cells (APCs)), as artificial Antigen Presenting Cells (aAPCs, to directly activate T cells), and as drug delivery vehicles (to support activated T cells).
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DOI：
10.1158/1078-0432.ccr-14-2696
发表时间：
2015-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bruns H;Bessell C;Varela JC;Haupt C;Fang J;Pasemann S;Mackensen A;Oelke M;Schneck JP;Schütz C
通讯作者：
Schütz C
影响因子：
10.8
作者：
Delcassian D;Depoil D;Rudnicka D;Liu M;Davis DM;Dustin ML;Dunlop IE
通讯作者：
Dunlop IE
影响因子：
10.8
作者：
Batista de Faria, Paula Cristina;dos Santos, Luara Isabela;Gazzinelli, Ricardo Tostes
通讯作者：
Gazzinelli, Ricardo Tostes
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
17.1
作者：
Anselmo, Aaron C.;Zhang, Mengwen;Mitragotri, Samir
通讯作者：
Mitragotri, Samir