A genome-wide association study of gestational diabetes mellitus in Korean women.
A genome-wide association study of gestational diabetes mellitus in Korean women.
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作者：
Kwak SH;Kim SH;Cho YM;Go MJ;Cho YS;Choi SH;Moon MK;Jung HS;Shin HD;Kang HM;Cho NH;Lee IK;Kim SY;Han BG;Jang HC;Park KS
关于妊娠期糖尿病（GDM）的遗传风险位点的知识仍然有限。在这项研究中，我们进行了两个阶段的全基因组关联分析韩国妇女。在第1阶段基因组扫描中，使用219万个基因分型或插补标记比较了468名GDM女性和1,242名非糖尿病对照女性。我们在931例病例和783例对照的第2阶段样本中选择了11个位点进行进一步的基因分型。通过荟萃分析分析1期和2期研究的联合效应。我们还研究了已知的2型糖尿病变异体在GDM中的作用。在联合分析中，已知与2型糖尿病相关的两个基因座与GDM在全基因组范围内具有显著相关性。rs7754840是CDKAL 1的一个变异体，与GDM的相关性最强（优势比1.518; P = 6.65 × 10−16）。MTNR 1B附近的一个变异rs 10830962也与GDM的风险显著相关（1.454; P = 2.49 × 10−13）。我们发现，已知的2型糖尿病变异与GDM之间的关联超过了零假设下的预期。总之，我们已经证实，CDKAL 1和MTNR 1B附近的遗传变异与韩国女性GDM密切相关。GDM和2型糖尿病之间似乎有共同的遗传基础。
Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. In the stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control women were compared using 2.19 million genotyped or imputed markers. We selected 11 loci for further genotyping in stage 2 samples of 931 case and 783 control subjects. The joint effect of stage 1 plus stage 2 studies was analyzed by meta-analysis. We also investigated the effect of known type 2 diabetes variants in GDM. Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in CDKAL1, had the strongest association with GDM (odds ratio 1.518; P = 6.65 × 10−16). A variant near MTNR1B, rs10830962, was also significantly associated with the risk of GDM (1.454; P = 2.49 × 10−13). We found that there is an excess of association between known type 2 diabetes variants and GDM above what is expected under the null hypothesis. In conclusion, we have confirmed that genetic variants in CDKAL1 and near MTNR1B are strongly associated with GDM in Korean women. There seems to be a shared genetic basis between GDM and type 2 diabetes.
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影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
8.2
作者：
Cho, Y. M.;Kim, T. H.;Jang, H. C.
通讯作者：
Jang, H. C.
影响因子：
5.8
作者：
Lauenborg, Jeannet;Grarup, Niels;Hansen, Torben
通讯作者：
Hansen, Torben
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
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