Behaviorally elicited heart rate reactivity and atherosclerosis in ovariectomized cynomolgus monkeys (Macaca fascicularis).
Behaviorally elicited heart rate reactivity and atherosclerosis in ovariectomized cynomolgus monkeys (Macaca fascicularis).
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行为引起去势食蟹猴（Macaca fasciculis）的心率反应性和动脉粥样硬化。
DOI：
10.1161/01.atv.17.9.1774
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Kaplan,JR
中科院分区：
文献类型：
--
作者：
Manuck,SB;Adams,MR;McCaffery,JM;Kaplan,JR
据推测，在对心理压力表现出较高的心血管反应的个体中，动脉粥样硬化的形成会加速。我们之前曾报道过，喂食胆固醇的雄性和生殖完整（绝经前）雌性食蟹猴的冠状动脉粥样硬化在对引起恐惧的实验室压力源经历最大心率（HR）反应的动物中加剧。在本文中，我们报告了 20 只雌性猴子（通过卵巢切除术）缺乏雌激素，随后接受雌激素和黄体酮替代疗法的雌性猴子之间存在类似的关系。在 30 个月的研究期开始时，为动物安装心电图遥测设备，并在基线和应激条件下记录它们的心率。应激心率测量是在标准挑战过程中获得的，其中包括受威胁的捕获和对动物的物理处理。作为相关实验的一部分，猴子被切除卵巢，并在余下的研究中，通过皮下硅橡胶植入物（道康宁公司）注射 17β-雌二醇（连续）和黄体酮（周期性）。动物自始至终都食用含胆固醇的饮食，并在第 24 个月重复进行 HR 测量。尸检时，动物对压力的 HR 反应幅度与左冠状动脉前降支和回旋支内膜面积测量值显着相关（分别为 r=.59 和 r=.57；P<.009）。这种关联是由于动物中冠状动脉粥样硬化的显着恶化（占反应性分布的上三分之一）。尽管总胆固醇和高密度脂蛋白胆固醇浓度也与 HR 反应性相关，但在对血浆脂质的伴随变化进行统计调整后，“高”HR 反应性的动脉粥样硬化仍然存在。 HR 反应性与血压、体重或社会行为无关。
It has been hypothesized that atherogenesis is accelerated among individuals who exhibit heightened cardiovascular reactions to psychologic stress. We have reported previously that the coronary atherosclerosis of cholesterol-fed, male and reproductively intact (premenopausal) female cynomolgus monkeys was exacerbated in animals that experienced the largest heart rate (HR) reactions to a fear-eliciting laboratory stressor. In this article, we report a similar relationship among 20 female monkeys that were rendered estrogen-deficient (by ovariectomy) and subsequently treated with replacement of both estrogen and progesterone. At the beginning of a 30-month study period, animals were fitted with ECG telemetry devices, and their HRs were recorded under baseline and stressed conditions. Stress HR measurements were obtained during a standard challenge involving threatened capture and physical handling of the animals. As part of a related experiment, monkeys were then ovariectomized and, for the remainder of the study, administered 17β-estradiol (continuously) and progesterone (cyclically) by subcutaneous Silastic implant (Dow Corning). Animals consumed a cholesterol-containing diet throughout, and HR measurements were repeated in the 24th month. At necropsy, the magnitude of animals’ HR responses to stress correlated significantly with intimal area measurements in the left anterior descending and circumflex coronary arteries (r=.59 andr=.57, respectively;P<.009). This association was due to a marked exacerbation of coronary atherosclerosis in animals comprising the upper third of the reactivity distribution. Although total and HDL cholesterol concentrations also covaried with HR reactivity, the greater atherosclerosis of “high” HR reactors persisted after statistical adjustment for concomitant variability in plasma lipids. HR reactivity was unrelated to blood pressure, body weight, or social behavior.
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影响因子：
3.3
作者：
J. Dimsdale;A. Herd;H. Hartley
通讯作者：
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DOI：
10.1007/978-1-4899-0697-7_6
发表时间：
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期刊：
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DOI：
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1990-11-01
期刊：
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影响因子：
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作者：
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通讯作者：
CLARKSON, TB
DOI：
10.1161/01.atv.10.2.164
发表时间：
1990-03-01
期刊：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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