New insights into Rho signaling from plant ROP/Rac GTPases.

New insights into Rho signaling from plant ROP/Rac GTPases.
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DOI:
10.1016/j.tcb.2012.05.002
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发表时间:
2012-09
影响因子:
19
通讯作者:
Yang Z
Yang Z
中科院分区:
生物学1区
文献类型:
--
作者:
Craddock C;Lavagi I;Yang Z

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在动物和植物细胞中,需要建立细胞极性的广泛的关键细胞过程由Rho-GTP酶控制。然而,与动物和酵母相反,植物具有称为ROP(来自植物的Rho样GTP酶)的单个Rho-GTP酶亚家族。这就提出了一个问题,即植物如何实现极性细胞过程所需的高水平调节。越来越明显的是,植物已经进化出特定的调节剂,包括ROP-鸟嘌呤交换因子(GEF)和Rop-相互作用的CRIB基序蛋白(RIC)效应物。近年来的研究表明,ROP的时空动力学、细胞骨架、内吞作用和胞吐作用是相互交织的。这篇综述的重点是拟议的自组织性质的ROP在植物和ROP介导的细胞机制相比,那些负责在动物和酵母细胞极性。
In animal and plant cells, a wide range of key cellular processes that require the establishment of cell polarity are governed by Rho-GTPases. In contrast to animals and yeast, however, plants possess a single Rho-GTPase subfamily called ROP (Rho-like GTPases from plants). This raises the question of how plants achieve the high level of regulation required for polar cellular processes. It is becoming evident that plants have evolved specific regulators, including ROP-Guanine Exchange Factors (GEFs) and the Rop-interactive CRIB motif–containing proteins (RIC) effectors. Recent research shows that the spatiotemporal dynamics of ROPs, the cytoskeleton, endocytosis and exocytosis are intertwined. This review focuses on the proposed self-organizing nature of ROPs in plants and how ROP-mediated cellular mechanisms compare with those responsible for cell polarity in animals and yeast.
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