Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel with antibacterial and anti-inflammatory effects for periodontitis treatment.
Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel with antibacterial and anti-inflammatory effects for periodontitis treatment.
复制标题
负载地塞米松沸石咪唑酯框架纳米复合水凝胶具有抗菌和抗炎作用，用于牙周炎治疗
DOI：
10.1016/j.mtbio.2022.100360
复制
发表时间：
2022-12
影响因子：
8.2
通讯作者：
Jiang, Liting
中科院分区：
文献类型：
--
作者：
Li, Ning;Xie, Lianyan;Wu, Yicheng;Wu, Yan;Liu, Yongjia;Gao, Yiming;Yang, Jie;Zhang, Xiuyin;Jiang, Liting
关键词：
牙周炎是一种细菌引起的慢性炎症性疾病，其特征是牙齿支持结构的进行性破坏。传统手法清创后，牙周深囊内的致病菌仍会导致局部炎症微环境的形成，这是一个具有挑战性的问题，迫切需要更好的治疗策略。在这里，我们集成了金属有机框架（MOFs）和水凝胶的优点，通过将地塞米松负载的沸石咪唑骨架-8（DZIF）纳米粒子掺入甲基丙烯酸聚磷酸酯（PPEMA）和甲基丙烯酸明胶（GelMA）的光交联基质中，制备可注射的纳米复合水凝胶。这种可注射的水凝胶可以很容易地注射到深层牙周袋中，达到高的局部浓度，而不会导致抗生素耐药性。纳米复合水凝胶具有高的抗菌活性，并且具有稳定微环境的构建体在体外维持细胞活力、增殖、扩散以及成骨，并且下调炎症基因表达。当在实验性牙周炎大鼠模型上进行评估时，显微计算机断层扫描和组织学分析表明，纳米复合物水凝胶有效地减少了牙周炎大鼠模型中的牙周炎症并减轻了炎症诱导的骨丢失。这些结果表明，纳米复合水凝胶可能是一个有前途的治疗牙周病的候选人。
Periodontitis is a bacterial-induced, chronic inflammatory disease characterized by progressive destruction of tooth-supporting structures. Pathogenic bacteria residing in deep periodontal pockets after traditional manual debridement can still lead to local inflammatory microenvironment, which remains a challenging problem and an urgent need for better therapeutic strategies. Here, we integrated the advantages of metal-organic frameworks (MOFs) and hydrogels to prepare an injectable nanocomposite hydrogel by incorporating dexamethasone-loaded zeolitic imidazolate frameworks-8 (DZIF) nanoparticles into the photocrosslinking matrix of methacrylic polyphosphoester (PPEMA) and methacrylic gelatin (GelMA). The injectable hydrogel could be easily injected into deep periodontal pockets, achieving high local concentrations without leading to antibiotic resistance. The nanocomposite hydrogel had high antibacterial activity and constructs with stable microenvironments maintain cell viability, proliferation, spreading, as well as osteogenesis, and down-regulated inflammatory genes expression in vitro. When evaluated on an experimental periodontitis rat model, micro-computed tomography and histological analyses showed that the nanocomposite hydrogel effectively reduced periodontal inflammation and attenuated inflammation-induced bone loss in a rat model of periodontitis. These findings suggest that the nanocomposite hydrogel might be a promising therapeutic candidate for treating periodontal disease.
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DOI：
10.3390/ma11101802
发表时间：
2018-09-22
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Lasserre JF;Brecx MC;Toma S
通讯作者：
Toma S
影响因子：
3.7
作者：
Abranches J;Zeng L;Kajfasz JK;Palmer SR;Chakraborty B;Wen ZT;Richards VP;Brady LJ;Lemos JA
通讯作者：
Lemos JA
甲状旁腺激素对老年大鼠血管化骨再生和种植体骨整合的早期影响
影响因子：
14
作者：
Jiang, Liting;Zhang, Wenjie;Jiang, Xinquan
通讯作者：
Jiang, Xinquan
轻松合成Ag@ZIF-8核壳异质结构纳米线以提高抗菌活性
影响因子：
6.7
作者：
Guo, Yu-Feng;Fang, Wei-Jun;Wang, Chun-Chang
通讯作者：
Wang, Chun-Chang
影响因子：
15.5
作者：
Galimanas V;Hall MW;Singh N;Lynch MD;Goldberg M;Tenenbaum H;Cvitkovitch DG;Neufeld JD;Senadheera DB
通讯作者：
Senadheera DB