Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro
Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro
复制标题
小鼠骨骼肌球蛋白重链基因转录本体内外发育模式
DOI:
10.1016/0092-8674(87)90762-8
复制
发表时间:
1987
期刊:
影响因子:
64.5
通讯作者:
M. Buckingham
中科院分区:
文献类型:
--
作者:
A. Weydert;P. Barton;A. Harris;C. Pinset;M. Buckingham
We have studied the transcripts of the embryonic, perinatal, and adult fast myosin heavy chain (MHC) genes in mouse skeletal muscle in vivo before and after birth, and in vitro in myogenic cell lines. In vivo, in 15-day fetal muscle, embryonic and perinatal MHC mRNAs an? both present, and the former is the major transcript. By 18 days the perinatal is predominant and the adult MHC mRNA appears. In P-bungarotoxintreated fetuses, a similar developmental pattern is detected, suggesting that it is nerve-independent and that primary myotubes alone undergo the same developmental changes. In vitro, in the absence of the nerve, embryonic, perinatal, and adult IIB MHC mRNAs accumulate. The level of the latter two isomRNAs is influenced by culture conditions.
登录
查看更多内容
影响因子:
2.7
作者:
Ewton,DZ;Florini,JR
通讯作者:
Florini,JR
DOI:
--
发表时间:
1984
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Hill,A;Hardies,SC;Phillips,SJ;Davis,MG;Hutchison3rd,CA;Edgell,MH
通讯作者:
Edgell,MH
影响因子:
5.6
作者:
Mohan,S;Linkhart,T;Rosenfeld,R;Baylink,D
通讯作者:
Baylink,D
DOI:
10.1073/pnas.81.4.1122
发表时间:
1984
影响因子:
11.1
作者:
Matsuda,R;Spector,D;Strohman,RC
通讯作者:
Strohman,RC
影响因子:
2.7
作者:
Gordon,H;VanEssen,DC
通讯作者:
VanEssen,DC