Risk factors and demographics for microtia in South America: a case-control analysis.
Risk factors and demographics for microtia in South America: a case-control analysis.
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DOI：
10.1002/bdra.23193
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发表时间：
2013-11
影响因子：
--
通讯作者：
Castilla, Eduardo E.
中科院分区：
文献类型：
--
作者：
Luquetti, Daniela V.;Saltzman, Babette S.;Lopez-Camelo, Jorge;Dutra, Maria da Graca;Castilla, Eduardo E.
在大多数病例中，小耳症的发病机制仍然未知，特别是对于患有孤立性小耳症的个体。我们的目的是使用病例对照方法评估这种情况的潜在风险因素。我们分析了 1982 年至 2011 年间参加 ECLAMC 研究（Estudio Colaborativo Latino Americano de Malformaciones Congénitas）的 1,194 例孤立性小耳畸形活产儿及其各自的对照数据。使用条件逻辑回归模型估计优势比，并使用所得优势比估计值的 95% 置信区间来控制调整后 OR (aOR) 的潜在混杂因素（性别、产妇年龄、医院和出生年份）的影响。与初产相比，多产与较高的小耳畸形风险相关（aOR 1.5，95%CI 1.2-1.8），其中曾怀孕过八次或以上的女性出现小耳畸形的风险最高（aOR 2.8，95%CI 1.6-5.2）。出现类似感冒症状的女性患小耳症的风险较高（aOR 2.2，95%CI 1.2–3.9），以及怀孕期间吸烟或饮酒的女性（aOR 1.7，95%CI 1.1–2.5 和 aOR 1.4，95%CI 0.9–2.1）。与饮酒的关联似乎仅限于那些报告在怀孕期间酗酒的女性（aOR 1.4，95% 0.7-2.9）。低海拔（< 2,500 m）医院的病例往往比高海拔医院的病例有更严重的小耳畸形类型。这些结果支持这样的假设：除了致畸剂之外，其他非遗传风险因素也会导致孤立性小耳畸形的发生。
The etiopathogenesis of microtia is still unknown in the majority of the cases, particularly for individuals presenting with isolated microtia. Our aim was to evaluate potential risk factors for this condition using a case-control approach. We analyzed data from 1,194 livebirths with isolated microtia enrolled in the ECLAMC study (Estudio Colaborativo Latino Americano de Malformaciones Congénitas) from 1982 to 2011 and their respective controls. Odds ratios were estimated with conditional logistic regression models along with 95% confidence intervals for the resulting odds ratio estimates controlling for the effects of potential confounders (sex, maternal age, hospital and year of birth) for an adjusted OR (aOR). Multiparity was associated with a higher risk of microtia compared to primiparity (aOR 1.5, 95%CI 1.2–1.8), with women who had eight or more prior pregnancies having the highest risk (aOR 2.8, 95%CI 1.6–5.2). Women who presented with cold-like symptoms were at higher risk for microtia (aOR 2.2, 95%CI 1.2–3.9) as well as those that used tobacco or alcohol during pregnancy (aOR 1.7, 95%CI 1.1–2.5 and aOR 1.4, 95%CI 0.9–2.1, respectively). The association with alcohol use appeared to be limited to those women who reported binge drinking during pregnancy (aOR 1.4, 95% 0.7–2.9). Cases from hospitals at low altitude (< 2,500 m) tended to have more severe types of microtia than those from hospitals at high altitude. These results support the hypothesis that in addition to teratogens other non-genetic risk factors contribute to the occurrence of isolated microtia.
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影响因子：
4
作者：
Harris, J;Kallen, B;Robert, E
通讯作者：
Robert, E
影响因子：
1.2
作者：
Paput, Laszlo;Czeizel, Andrew E.;Banhidy, Ferenc
通讯作者：
Banhidy, Ferenc
影响因子：
2.9
作者：
Grisaru-Granovsky, Sorina;Gordon, Ethel-Sherry;Schimmel, Michael M.
通讯作者：
Schimmel, Michael M.
DOI：
10.1159/000080776
发表时间：
2004-01-01
期刊：
COMMUNITY GENETICS
影响因子：
--
作者：
Castilla, EE;Orioli, IM
通讯作者：
Orioli, IM
影响因子：
120.7
作者：
JICK, H;HOLMES, LB;STERGACHIS, A
通讯作者：
STERGACHIS, A