Hydrogen sulfide and vascular regulation - An update.
Hydrogen sulfide and vascular regulation - An update.
复制标题
硫化氢和血管调节 – 更新
DOI：
10.1016/j.jare.2020.05.007
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发表时间：
2021-01
影响因子：
10.7
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Lv B;Chen S;Tang C;Jin H;Du J;Huang Y
硫化氢（H2S）被认为是继一氧化碳（CO）和一氧化氮（NO）之后的第三大气体递质。它在调节血管稳态中起重要作用。血管重塑已被证明与受损的H2S生成有关。本文就H2S在血管生理和病理生理中的作用及其机制进行综述和讨论。内源性硫化氢（H2S）作为第三种气体递质，主要由酶促途径产生，并受多种代谢途径的调节。H2S作为一种生理性血管调节剂，抑制血管细胞增殖，调节其凋亡和自噬，控制血管张力。越来越多的证据表明，H2S通路的下调参与了多种血管疾病的发病机制，如高血压、动脉粥样硬化和肺动脉高压。另外，H2S补充可以通过调节血管张力、抑制血管炎症、保护免受氧化应激和增殖以及调节血管细胞凋亡来极大地帮助防止血管疾病的进展，这已经在动物和细胞实验中甚至在临床研究中得到验证。此外，H2S系统和血管紧张素转换酶（ACE）抑制剂在缓解缺血性心脏病和左心室功能障碍中起着重要作用。值得注意的是，含巯基的ACEI抑制剂佐芬普利优于其他ACE抑制剂，因为除了ACE抑制外，其还具有释放H2S的能力。新型H2S供体的设计和应用在血管相关疾病的治疗中具有重要的临床意义。然而，需要进一步研究H2S在血管生理学和病理生理学中的作用。
Hydrogen sulfide (H2S) is considered to be the third gasotransmitter after carbon monoxide (CO) and nitric oxide (NO). It plays an important role in the regulation of vascular homeostasis. Vascular remodeling have has proved to be related to the impaired H2S generation. This study aimed to summarize and discuss current data about the function of H2S in vascular physiology and pathophysiology as well as the underlying mechanisms. Endogenous hydrogen sulfide (H2S) as a third gasotransmitter is primarily generated by the enzymatic pathways and regulated by several metabolic pathways. H2S as a physiologic vascular regulator, inhibits proliferation, regulates its apoptosis and autophagy of vascular cells and controls the vascular tone. Accumulating evidence shows that the downregulation of H2S pathway is involved in the pathogenesis of a variety of vascular diseases, such as hypertension, atherosclerosis and pulmonary hypertension. Alternatively, H2S supplementation may greatly help to prevent the progression of the vascular diseases by regulating vascular tone, inhibiting vascular inflammation, protecting against oxidative stress and proliferation, and modulating vascular cell apoptosis, which has been verified in animal and cell experiments and even in the clinical investigation. Besides, H2S system and angiotensin-converting enzyme (ACE) inhibitors play a vital role in alleviating ischemic heart disease and left ventricular dysfunction. Notably, sulfhydryl-containing ACEI inhibitor zofenopril is superior to other ACE inhibitors due to its capability of H2S releasing, in addition to ACE inhibition. The design and application of novel H2S donors have significant clinical implications in the treatment of vascular-related diseases. However, further research regarding the role of H2S in vascular physiology and pathophysiology is required.
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影响因子：
37.8
作者：
Calvert JW;Elston M;Nicholson CK;Gundewar S;Jha S;Elrod JW;Ramachandran A;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
2.2
作者：
Cacanyiova, S.;Majzunova, M.;Berenyiova, A.
通讯作者：
Berenyiova, A.
DOI：
10.1177/1470320316656480
发表时间：
2016-10
期刊：
Journal of the renin-angiotensin-aldosterone system : JRAAS
影响因子：
--
作者：
Borghi C;Omboni S;Novo S;Vinereanu D;Ambrosio G;Ambrosioni E;SMILE-4 Working Party
通讯作者：
SMILE-4 Working Party
影响因子：
5.3
作者：
Aghagolzadeh, Parisa;Radpour, Ramin;Pasch, Andreas
通讯作者：
Pasch, Andreas
影响因子：
--
作者：
Banerjee R;Chiku T;Kabil O;Libiad M;Motl N;Yadav PK
通讯作者：
Yadav PK