Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.
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蛋白质摄入与肌肉质量增加之间的剂量反应关系:随机对照试验的系统综述和荟萃分析。

DOI:
10.1093/nutrit/nuaa104
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发表时间:
2020-11-04
期刊:
影响因子:
6.1
通讯作者:
Miyachi M
Miyachi M
中科院分区:
医学2区
文献类型:
--
作者:
Tagawa R;Watanabe D;Ito K;Ueda K;Nakayama K;Sanbongi C;Miyachi M

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去脂体重对于健康至关重要,但关于蛋白质干预措施在增加去脂体重方面的有效性尚缺乏共识。本系统评价的目的是评估蛋白质摄入量对去脂体重影响的剂量-反应关系。 PubMed 和 Ichushi-Web 数据库以电子方式检索,并手动检索此处包含的文献和其他荟萃分析中的参考文献列表。其中包括评估蛋白质摄入量对去脂体重影响的随机对照试验。两位作者独立筛选摘要; 5 审阅全文。共有来自 105 篇文章的 5402 名研究参与者。在多变量样条模型中,每天蛋白质摄入量增加 0.1 g/kg 时,去脂体重的平均增加分别比总蛋白质摄入量 1.3 g/kg/d 低 0.39 kg (95% CI, 0.36–0.41) 和 0.12 kg (95% CI, 0.11–0.14)。这些发现表明,在 0.5 至 3.5 g/kg/d 的剂量范围内,以剂量依赖性方式持续几个月将当前蛋白质摄入量略微增加 0.1 g/kg/d 可能会增加或维持去脂体重。 UMIN 注册号 UMIN000039285。
Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking. The aim of this systematic review was to evaluate the dose–response relationship of the effects of protein intake on lean body mass. The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manually. Randomized controlled trials evaluating the effects of protein intake on lean body mass were included. Two authors independently screened the abstracts; 5 reviewed the full texts. A total of 5402 study participants from 105 articles were included. In the multivariate spline model, the mean increase in lean body mass associated with an increase in protein intake of 0.1 g/kg of body weight per day was 0.39 kg (95%CI, 0.36–0.41) and 0.12 kg (95%CI, 0.11–0.14) below and above the total protein intake of 1.3 g/kg/d, respectively. These findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg/d in a dose-dependent manner over a range of doses from 0.5 to 3.5 g/kg/d may increase or maintain lean body mass. UMIN registration number UMIN000039285.
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