Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.
Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.
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DOI：
10.1016/j.biomaterials.2011.11.020
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发表时间：
2012-02
期刊：
影响因子：
14
通讯作者：
Yun, Chae-Ok
中科院分区：
文献类型：
--
作者：
Kim, Jaesung;Kim, Pyung-Hwan;Kim, Sung Wan;Yun, Chae-Ok
由于系统给药的腺病毒（Ad）会被先天/适应性免疫反应和肝脏内的积累迅速消灭，因此Ad载体在体内的应用受到严格限制。为了成功开发用于癌症治疗的Ad载体系统，用聚合物对Ad载体进行化学或物理修饰已被普遍用作克服障碍的一种有前途的策略。以聚乙二醇（PEG）为首，各种聚合物被开发用于屏蔽治疗性Ad载体的表面，并很好地完成了延长血液循环时间和减少肝毒性。然而，尽管聚合物包被的ad可以通过增强的渗透性和滞留（EPR）效应成功地从体内的一系列保护系统中撤离并定位到肿瘤内，但进入目标细胞的可能性却很少。为了将靶向部分赋予聚合物包被的Ad载体，引入了多种配体，如肿瘤归家肽、生长因子或抗体，以避免不必要的转导并提高治疗效果。在这里，我们将描述和分类的特征发表的聚合物与Ad向量。此外，我们还将比较可变靶向配体的性质，这些配体正被用于主动寻址聚合物包被的Ad载体。
With the reason that systemically administered adenovirus (Ad) is rapidly extinguished by innate/adaptive immune responses and accumulation in liver, in vivo application of the Ad vector is strictly restricted. For achieving to develop successful Ad vector systems for cancer therapy, the chemical or physical modification of Ad vectors with polymers has been generally used as a promising strategy to overcome the obstacles. With polyethylene glycol (PEG) first in order, a variety of polymers have been developed to shield the surface of therapeutic Ad vectors and well accomplished to extend circulation time in blood and reduce liver toxicity. However, although polymer-coated Ads can successfully evacuate from a series of guarding systems in vivo and locate within tumors by enhanced permeability and retention (EPR) effect, the possibility to entering into the target cell is few and far between. To endow targeting moiety to polymer-coated Ad vectors, a diversity of ligands such as tumor-homing peptides, growth factors or antibodies, have been introduced with avoiding unwanted transduction and enhancing therapeutic efficacy. Here, we will describe and classify the characteristics of the published polymers with respect to Ad vectors. Furthermore, we will also compare the properties of variable targeting ligands, which are being utilized for addressing polymer-coated Ad vectors actively.
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DOI：
10.1016/j.urolonc.2007.05.011
发表时间：
2007-09-01
影响因子：
2.7
作者：
Black, Peter C.;Agarwal, Piyush K.;Dinney, Colin P. N.
通讯作者：
Dinney, Colin P. N.
影响因子：
5.1
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
CHERESH, DA
影响因子：
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作者：
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通讯作者：
Yun, C-O