Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics.
Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics.
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DOI：
10.1007/s11682-023-00773-7
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发表时间：
2023-10
影响因子：
3.2
通讯作者：
Mayer, Laurel
中科院分区：
文献类型：
--
作者：
Rapuano, Kristina M. M.;Tejavibulya, Link;Dinc, Eda Naz;Li, Anfei;Davis, Haley;Korn, Rachel;Leibel, Rudolph L. L.;Walsh, B. Timothy;Ranzenhofer, Lisa;Rosenbaum, Michael;Casey, B. J.;Mayer, Laurel
儿童肥胖是一个主要的公共卫生问题。遗传易感性和高能量食物的增加是肥胖的已知风险因素。然而，这些因素在多大程度上共同使行为和神经回路偏向于儿童肥胖增加仍不清楚。在接受fMRI时，108名儿童（5- 11岁）进行了食物特定的go/no-go任务。参与者被指示对食物或玩具的图像做出反应（“去”）或抑制反应（“不去”）。一半的试验描绘了高热量食物（例如，比萨饼）而另一半描绘低热量食物（例如，沙拉）。儿童还进行了与能量摄入和肥胖相关的DNA多态性（FTO rs 9939609）的基因分型，以检查肥胖风险对行为和大脑对食物反应的影响。参与者表现出对高热量和低热量食物图像的行为敏感性差异，这取决于任务要求。当对中性刺激（即，玩具）和更差的检测玩具时，对高热量食物的反应。抑制失败伴随着显著性网络活动（前扣带皮层，背侧前扣带皮层），这是由食物图像的错误警报驱动的。肥胖遗传风险较高的儿童（FTO基因型的剂量依赖模型）表现出明显的大脑和行为关系，例如遗传风险与对高热量食物图像的敏感性增加和前额叶活动增加有关。这些研究结果表明，高热量食物可能对儿童发展饮食习惯，促进肥胖的风险特别突出。在线版本包含补充材料，可通过10.1007/s11682-023-00773-7获得。
Pediatric obesity is a major public health concern. Genetic susceptibility and increased availability of energy-dense food are known risk factors for obesity. However, the extent to which these factors jointly bias behavior and neural circuitry towards increased adiposity in children remains unclear. While undergoing fMRI, 108 children (ages 5-11y) performed a food-specific go/no-go task. Participants were instructed to either respond (“go”) or inhibit responding (“no-go”) to images of food or toys. Half of the runs depicted high-calorie foods (e.g., pizza) whereas the other half depicted low-calorie foods (e.g., salad). Children were also genotyped for a DNA polymorphism associated with energy intake and obesity (FTO rs9939609) to examine the influence of obesity risk on behavioral and brain responses to food. Participants demonstrated differences in behavioral sensitivity to high- and low-calorie food images depending on task demands. Participants were slower but more accurate at detecting high- (relative to low-) calorie foods when responding to a neutral stimulus (i.e., toys) and worse at detecting toys when responding to high-calorie foods. Inhibition failures were accompanied by salience network activity (anterior insula, dorsal anterior cingulate cortex), which was driven by false alarms to food images. Children at a greater genetic risk for obesity (dose-dependent model of the FTO genotype) demonstrated pronounced brain and behavioral relationships such that genetic risk was associated with heightened sensitivity to high-calorie food images and increased anterior insula activity. These findings suggest that high-calorie foods may be particularly salient to children at risk for developing eating habits that promote obesity. The online version contains supplementary material available at 10.1007/s11682-023-00773-7.
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影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
DOI：
10.1111/j.1532-7795.2010.00712.x
发表时间：
2011-03-01
期刊：
Journal of research on adolescence : the official journal of the Society for Research on Adolescence
影响因子：
--
作者：
Casey B;Jones RM;Somerville LH
通讯作者：
Somerville LH
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
8.1
作者：
Décarie-Spain L;Sharma S;Hryhorczuk C;Issa-Garcia V;Barker PA;Arbour N;Alquier T;Fulton S
通讯作者：
Fulton S
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.