Cellular and humoral immunity of virus-induced asthma.
Cellular and humoral immunity of virus-induced asthma.
复制标题
病毒诱导的哮喘的细胞和体液免疫。
DOI：
10.3389/fmicb.2013.00252
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发表时间：
2013
影响因子：
5.2
通讯作者：
Okayama Y
中科院分区：
文献类型：
--
作者：
Okayama Y
在绝大多数情况下，哮喘发病与呼吸道病毒感染有关，特别是呼吸道合胞病毒（RSV）和/或人鼻病毒（HRV）感染。然而，为什么RSV和HRV在儿童早期诱发大多数毛细支气管炎病例以及为什么只有一小部分RSV和HRV诱发的毛细支气管炎儿童后来发展为哮喘的原因尚不清楚。一项遗传关联研究揭示了哮喘患者病毒性疾病和遗传变异之间的重要相互作用。严重的RSV和HRV诱导的细支气管炎可能与RSV和HRV的先天免疫应答缺陷有关。先天性免疫应答缺陷和调节性T细胞功能障碍的婴儿中RSV和HRV感染被认为是哮喘发展的危险因素。从出生后第一年开始，对空气过敏原的敏感性始终使儿童易患HRV诱导的喘息性疾病，但匡威则不然。存在病毒特异性的一些证据，因为过敏性致敏特异性地增加了HRV感染个体的喘息风险，但不是RSV。帕利珠单抗是一种靶向RSV融合蛋白A抗原位点的人源化单克隆抗体，其给药可降低高危婴儿的住院风险和喘息复发风险。然而，帕利珠单抗对有特应性家族史的儿童随后的复发性喘息没有任何影响。这些结果表明，RSV感染和HRV感染可能分别通过特异性独立和特异性依赖机制使个体易患反复喘息。呼吸道病毒引起的喘息性疾病可能包括以不同方式与哮喘相关的多种亚表型。
Asthma inception is associated with respiratory viral infection, especially infection with respiratory syncytial virus (RSV) and/or human rhinovirus (HRV), in the vast majority of cases. However, the reason why RSV and HRV induce the majority of bronchiolitis cases during early childhood and why only a small percentage of children with RSV- and HRV-induced bronchiolitis later develop asthma remains unclear. A genetic association study has revealed the important interaction between viral illness and genetic variants in patients with asthma. Severe RSV- and HRV-induced bronchiolitis may be associated with a deficiency in the innate immune response to RSV and HRV. RSV and HRV infections in infants with deficient innate immune response and the dysfunction of regulatory T cells are considered to be a risk factor for the development of asthma. Sensitization to aeroallergens, beginning in the first year of life, consistently predisposes children to HRV-induced wheezing illnesses, but the converse is not true. Some evidence of virus specificity exists, in that allergic sensitization specifically increased the risk of wheezing in individuals infected with HRV, but not RSV. Administration of Palivizumab, a humanized monoclonal antibody that targets the A antigenic site of the Fusion-protein of RSV, decreases the risk of hospitalization in high-risk infants and the risk of recurrent of wheezing. However, palivizumab did not have any effect on subsequent recurrent wheezing in children with a family history of atopy. These findings suggest that infection with RSV and infection with HRV might predispose individuals to recurrent wheezing through an atopy-independent and an atopy-dependent mechanism, respectively. Respiratory virus-induced wheezing illnesses may encompass multiple sub-phenotypes that relate to asthma in different ways.
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影响因子：
5.1
作者：
GLEZEN, WP;PAREDES, A;FRANK, AL
通讯作者：
FRANK, AL
影响因子：
3.6
作者：
Garcia, Carla;Soriano-Fallas, Alejandra;Mejias, Asuncion
通讯作者：
Mejias, Asuncion
影响因子：
14.2
作者：
Dakhama, Azzeddine;Lee, Young-Mok;Gelfand, Erwin W.
通讯作者：
Gelfand, Erwin W.
影响因子：
6.4
作者：
HEILMAN, CA
通讯作者：
HEILMAN, CA
影响因子：
4.4
作者：
Dakhama, A;Park, JW;Gelfand, EW
通讯作者：
Gelfand, EW