Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex.
Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex.
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Gas2l3，一种新型收缩位点相关蛋白，其调节由 APC/C Cdh1 复合物介导。
DOI：
10.1371/journal.pone.0057532
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tzur A
中科院分区：
文献类型：
--
作者：
Pe'er T;Lahmi R;Sharaby Y;Chorni E;Noach M;Vecsler M;Zlotorynski E;Steen H;Steen JA;Tzur A
Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free systems from both frog eggs and human cells, we show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/CCdh1 complex, but not by the APC/CCdc20 complex, and is phosphorylated by Cdk1 in mitosis. Moreover, late in cytokinesis, Gas2l3 is exclusively localized to the constriction sites, which are the narrowest parts of the intercellular bridge connecting the two daughter cells. Overexpression of Gas2l3 specifically interferes with cell abscission, which is the final stage of cell division, when the cutting of the intercellular bridge at the constriction sites occurs. We therefore suggest that Gas2l3 is part of the cellular mechanism that terminates cell division.
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影响因子：
3.7
作者：
Zhang T;Dayanandan B;Rouiller I;Lawrence EJ;Mandato CA
通讯作者：
Mandato CA
DOI：
10.1083/jcb.200309035
发表时间：
2004-01-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lindon C;Pines J
通讯作者：
Pines J
DOI：
10.1073/pnas.0912802107
发表时间：
2010-01-26
影响因子：
11.1
作者：
Wu, Tao;Merbl, Yifat;Kirschner, Marc W.
通讯作者：
Kirschner, Marc W.
影响因子：
56.9
作者：
Guizetti, Julien;Schermelleh, Lothar;Gerlich, Daniel W.
通讯作者：
Gerlich, Daniel W.
GAS2是一种生长逮捕特异性蛋白，是微丝网络系统的组成部分。
影响因子：
7.8
作者：
Brancolini, C;Bottega, S;Schneider, C
通讯作者：
Schneider, C