Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser.
Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser.
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DOI：
10.1371/journal.pone.0116305
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yoneya S
中科院分区：
文献类型：
--
作者：
Shoji T;Kuroda H;Suzuki M;Baba M;Hangai M;Araie M;Yoneya S
利用宽波长激光光源的原型光学相干断层扫描仪（OCT）测量水平和垂直筛板（LC）倾斜角并研究相关因素。横断面研究。入组了28只非青光眼眼（来自15名受试者）和25只青光眼眼（来自14名患者）。以10 µm的步长获得总共300个视神经乳头B扫描，并将Bruch膜开口（BMO）的内缘确定为参考平面。测量BMO线与LC表面最佳拟合线之间的垂直和水平角度，并采用单因素和多因素Logistic回归分析估计潜在的相关因素。无青光眼眼水平和垂直倾斜角的中位数（四分位距）分别为7.10（2.43-11.45）度和4.15（2.60-6.85）度，青光眼眼分别为8.50（4.40-14.10）度和9.30（6.90-14.15）度。使用多元逻辑回归分析，屈光不正与水平LC倾斜角（系数，-1.53/屈光度）具有统计学显著相关性，青光眼与垂直倾斜角（系数，6.56）具有显著相关性（p<0.001）。OCT允许评价LC与BMO相比的内部倾斜。水平向LC内倾角与屈光不正相关，对应于近视的生理变化;垂直向LC内倾角与青光眼相关，对应于青光眼的病理变化。这些参数对研究近视、青光眼与LC形态学特征之间的相关性具有重要意义。
To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source. Cross sectional study. Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured and potential associated factors were estimated with univariate and multivariate logistic regression analyses. The median (interquartile range) horizontal and vertical tilt angles were 7.10 (2.43–11.45) degrees and 4.15 (2.60–6.85) degrees in eyes without glaucoma and 8.50 (4.40–14.10) degrees and 9.30 (6.90–14.15) degrees in glaucoma eyes, respectively. The refractive errors had a statistically significant association with horizontal LC tilt angles (coefficients, −1.53 per diopter) and glaucoma had a significant correlation with vertical tilt angles (coefficients, 6.56) using multiple logistic regression analysis (p<0.001). OCT allowed evaluation of the internal tilting of the LC compared with the BMO. The horizontal internal LC tilt angle was correlated with refractive errors, corresponding to myopic physiological changes, and vertical internal LC tilt was correlated with glaucoma, corresponding to glaucomatous pathological changes. These parameters have important implications for investigation of the correlation between myopia, glaucoma and LC morphological features.
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