Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data sets.
Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data sets.
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DOI：
10.1167/iovs.08-2302
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发表时间：
2009-01
影响因子：
4.4
通讯作者：
Burgoyne CF
中科院分区：
文献类型：
--
作者：
Strouthidis NG;Yang H;Fortune B;Downs JC;Burgoyne CF
评估在非人灵长类（NHP）眼视神经乳头三维（3-D）组织形态计量学和3-D谱域光学相干断层扫描（SD-OCT）重建中检测神经管开口（NCO）及其特征的能力。在38名NHP的44只正常眼的3D组织形态测量重建的40个径向、矢状面内描绘NCO，每个灌注固定在IOP 10 mm Hg，以及从24名NHP的33只正常眼的单独组体内获得的3-D SD-OCT（Spectralis; Heidelberg Engineering，Heidelberg，德国）体积。在所有重建中，将最小二乘椭圆拟合到80个NCO点。对于每只眼睛，计算拟合椭圆的尺寸和平面误差（平面度的量规）。在每个组织形态测量和SD-OCT重建的每个切片内成功描绘了NCO。组织形态学和SD-OCT体积内的中位平面误差相似（8 μm，范围4-19，组织形态学，和10 μm，范围4-26，SD-OCT），并且相对于椭圆尺寸较小。中位组织形态测量椭圆尺寸为1453 μm（长轴，范围1218-1737）和1066 μm（短轴，范围808-1263）。中位SD-OCT椭圆尺寸为1512 μm（长轴，范围1191-1865）和1060 μm（短轴，范围772-1248）。在所有3-D组织形态测量和SD-OCT重建中，NCO在生物学上是连续的，并且相对平坦。这些特征支持其作为使用3-D SD-OCT的视神经乳头结构的横截面和纵向测量的参考平面的进一步评价。
To assess the ability to detect the neural canal opening (NCO) and its characteristics within three-dimensional (3-D) histomorphometric and 3-D spectral domain optical coherence tomography (SD-OCT) reconstructions of the optic nerve head from nonhuman primate (NHP) eyes. NCO was delineated within 40 radial, sagittal sections of 3-D histomorphometric reconstructions of 44 normal eyes of 38 NHPs, each perfusion fixed at IOP 10 mm Hg, and 3-D SD-OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany) volumes acquired in vivo from a separate group of 33 normal eyes of 24 NHPs. Within all reconstructions, a least-squares ellipse was fitted to the 80 NCO points. For each eye, the dimensions and plane error (a gauge of planarity) of the fitted ellipse were calculated. The NCO was successfully delineated within every section of each histomorphometric and SD-OCT reconstruction. Median plane error was similar within histomorphometric and SD-OCT volumes (8 μm, range 4–19, histomorphometry, and 10 μm, range 4–26, SD-OCT) and was small relative to the size of the ellipse. Median histomorphometric ellipse dimensions were 1453 μm (major axis, range 1218–1737) and 1066 μm (minor axis, range 808–1263). Median SD-OCT ellipse dimensions were 1512 μm (major axis, range 1191–1865) and 1060 μm (minor axis, range 772–1248). The NCO is biologically continuous and relatively planar within all 3-D histomorphometric and SD-OCT reconstructions. These characteristics support its further evaluation as a reference plane for cross-sectional and longitudinal measurement of optic nerve head structures using 3-D SD-OCT.
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影响因子：
4.2
作者：
Barkana, Yaniv;Harizman, Noga;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
3.4
作者：
Cepurna, WO;Kayton, RJ;Morrison, JC
通讯作者：
Morrison, JC
影响因子：
4.1
作者：
Garway-Heath, DF;Rudnicka, AR;Hitchings, RA
通讯作者：
Hitchings, RA
影响因子：
4.4
作者：
Leung, Christopher Kai-shun;Cheng, Arthur Chak Kwan;Lam, Dennis Shun Chiu
通讯作者：
Lam, Dennis Shun Chiu
DOI：
10.1007/bf00189355
发表时间：
1996-12-01
影响因子：
2.7
作者：
Jonas, JB;Grundler, A
通讯作者：
Grundler, A