Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography.
Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography.
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DOI：
10.1016/j.ophtha.2011.09.054
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发表时间：
2012-04
期刊：
影响因子：
13.7
通讯作者：
Chauhan BC
中科院分区：
文献类型：
--
作者：
Reis AS;Sharpe GP;Yang H;Nicolela MT;Burgoyne CF;Chauhan BC
应用光谱域光学相干断层扫描(SD-OCT)研究与临床视盘边缘相关的视神经头(ONH)解剖结构。横断面研究。有局灶性、弥漫性和硬化性视盘损害的开角型青光眼患者和年龄匹配的正常对照组。分析每个时钟小时以ONH为中心的高分辨率放射状SD-OCT B超。对于每一次扫描，Elschnig的边缘组织被分类为倾斜(内部倾斜、外部倾斜或非倾斜)，以及Bruchs膜是否悬于边缘组织之上。使用定制软件将光盘立体照片与SD-OCT数据进行共定位。立体照片中确定的椎间盘边缘与(1)Bruch膜开口，定义为Bruch膜最内侧边缘；(2)Bruch膜/边缘组织，定义为Bruch膜开口或边缘组织外的任一个方面；或(3)边缘组织，定义为B超中单独边缘组织的任何方面，在每个时钟小时计算。SD-OCT结构与立体照片中的盘缘重合。30例患者(每种类型各10例)和10例对照组，中位年龄分别为68.1岁(42-86岁)和63.5岁(42-77岁)。虽然28例(93%)有2个或更多的边缘组织构型，但最主要的是内斜的，主要是在上侧和鼻侧，经常伴有Bruch膜突出。外斜缘组织较少见，多见于低位和临床处。在对照组中，主要是在椎间盘周围有内部倾斜的结构。虽然患者和对照组之间的结构没有统计学上的差异，但他们属于3个青光眼组。在大多数位置，最常被识别为椎间盘边缘的SD-OCT结构是Bruch膜和边缘组织的某一方面，在Bruch膜开口之外。然而，在大多数青光眼患者和对照组中，Bruchs膜突出的区域存在，然而，在大多数情况下，视盘边缘看不到。临床感觉到的椎间盘边缘很可能不是SD-OCT检测到的Bruch膜最内侧边缘。这些发现对自动检测视盘边缘和估计神经视网膜边缘具有重要意义。
To characterize optic nerve head (ONH) anatomy related to the clinical optic disc margin with spectral domain optical coherence tomography (SD-OCT). Cross-sectional study. Open-angle glaucoma patients with focal, diffuse and sclerotic optic disc damage, and age-matched normal controls. High-resolution radial SD-OCT B-scans centered on the ONH were analyzed at each clock hour. For each scan, the border tissue of Elschnig was classified for obliqueness (internally oblique, externally oblique, or non-oblique), and presence of Bruch’s membrane overhang over border tissue. Optic disc stereo-photographs were co-localized to SD-OCT data with customized software. The frequency with which the disc margin identified in stereo-photographs coincided with (1) Bruch’s membrane opening, defined as the innermost edge of Bruch’s membrane; (2) Bruch’s membrane/border tissue, defined as any aspect of either, outside Bruch’s membrane opening or border tissue; or (3) border tissue, defined as any aspect of border tissue alone, in the B-scans was computed at each clock hour. SD-OCT structures coinciding with the disc margin in stereo-photographs. There were 30 patients (10 with each type of disc damage) and 10 controls, with median (range) age 68.1 (42–86) and 63.5 (42–77) years respectively. Although 28 (93%) patients had 2 or more border tissue configurations, the most predominant one was internally oblique, primarily superiorly and nasally, frequently with Bruch’s membrane overhang. Externally oblique border tissue was less frequent, observed mostly inferiorly and temporally. In controls, there was predominantly internally oblique configuration around the disc. While the configurations were not statistically different between patients and controls, they were among the 3 glaucoma groups. At most locations the SD-OCT structure most frequently identified as the disc margin was some aspect of Bruch’s membrane and border tissue, outside Bruch’s membrane opening. Bruch’s membrane overhang was regionally present in the majority of glaucoma patients and controls, however, in most cases not visible as the disc margin. The clinically perceived disc margin is most likely not the SD-OCT detected innermost edge of Bruch’s membrane. These findings have important implications for the automated detection of the disc margin and estimates of the neuroretinal rim.
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影响因子：
13.7
作者：
See, Jovina L. S.;Nicolela, Marcelo T.;Chauhan, Balwantray C.
通讯作者：
Chauhan, Balwantray C.
影响因子：
--
作者：
ASMAN, P;HEIJL, A
通讯作者：
HEIJL, A
影响因子：
13.7
作者：
Wojtkowski, M;Srinivasan, V;Duker, JS
通讯作者：
Duker, JS
影响因子：
4.2
作者：
Barkana, Yaniv;Harizman, Noga;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
4.4
作者：
Strouthidis NG;Yang H;Fortune B;Downs JC;Burgoyne CF
通讯作者：
Burgoyne CF