Complete Response to Combined Chemotherapy and Anti-PD-1 Therapy for Recurrent Gallbladder Carcinosarcoma: A Case Report and Literature Review.
Complete Response to Combined Chemotherapy and Anti-PD-1 Therapy for Recurrent Gallbladder Carcinosarcoma: A Case Report and Literature Review.
复制标题
DOI：
10.3389/fonc.2022.803454
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Liu QQ;Lin HM;Han HW;Yang CN;Liu C;Zhang R
胆囊癌肉瘤是一种罕见的恶性肿瘤，预后极差。虽然手术被认为是GBCS的主要治疗方法，但对于未切除病变的有效治疗策略一直不明确。我们报告一位74岁男性在当地医院接受胆囊癌根治性切除术。7个月后，他因右上腹不适住进我院。术后放射学检查显示肝脏多发病灶、肝门淋巴结转移和门静脉主干癌栓。病理会诊结果证实了GBCS，免疫组化检查显示20%的肿瘤细胞表达PD-L1。然后，患者接受化疗（吉西他滨+奥沙利铂，GEMOX）联合抗PD-1治疗。经过9个疗程的联合治疗后，肿瘤完全消退，至今没有复发的迹象。我们首次报道一例复发性GBCS患者，其受益于联合化疗和免疫治疗，为难治性恶性肿瘤提供了潜在的有效管理策略。
Gallbladder carcinosarcoma (GBCS) is a rare and aggressive malignancy with extremely poor prognosis. Although surgery is regarded as the primary therapy for GBCS, the effective therapeutic strategies for unresected lesions have been poorly defined. We presented a case of a 74-year-old male who underwent radical resection of gallbladder carcinoma at a local hospital. Seven months later, he was admitted to our hospital due to right upper abdominal discomfort. Postoperative radiological examinations showed multiple hepatic lesions, hilar lymph node metastasis, and main portal vein tumor thrombus. The pathological consultation results confirmed GBCS and immunohistochemical examinations revealed PD-L1 expression in 20% of tumor cells. Then, the patient received chemotherapy (Gemcitabine plus Oxaliplatin, GEMOX) in combination with anti-PD-1 therapy. After nine courses of the combination therapy, complete regression of the tumors was achieved with no evidence of relapse till now. We, for the first time, reported a patient with recurrent GBCS who benefited from the combined chemotherapy and immunotherapy, providing a potential effective management strategy for the refractory malignant tumor.
登录
查看更多内容
影响因子：
2.5
作者：
Kim, Ho-Hyun;Hur, Young-Hoe;Cho, Chol Kyoon
通讯作者：
Cho, Chol Kyoon
影响因子：
5.8
作者：
Orth, Martin F.;Buecklein, Veit Leonhard;Knoesel, Thomas
通讯作者：
Knoesel, Thomas
影响因子：
28.4
作者：
Kim, Richard D.;Chung, Vincent;Kim, Dae Won
通讯作者：
Kim, Dae Won
影响因子：
4.7
作者：
Gkika E;Hawkins MA;Grosu AL;Brunner TB
通讯作者：
Brunner TB
影响因子：
45.3
作者：
Daud, Adil I.;Wolchok, Jedd D.;Hamid, Omid
通讯作者：
Hamid, Omid