A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior.
A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior.
复制标题
一个建立应激诱导的饮食行为变化的具有转化相关性动物模型的框架
DOI：
10.1016/j.biopsych.2021.06.020
复制
发表时间：
2022-05-15
影响因子：
10.6
通讯作者：
Zeltser LM
中科院分区：
文献类型：
--
作者：
François M;Fernández-Gayol O;Zeltser LM
压力常常影响饮食行为，但它在一些人身上导致食量增加，在另一些人身上则导致食量减少。确定决定对压力的饮食反应方向的生理和心理因素一直是流行病学和临床研究的一个主要目标。然而，在人类中标准化压力暴露的挑战阻碍了揭示潜在机制的努力。是什么决定了压力诱导的进食反应方向这一问题在动物模型中尚未直接得到解决，但是将压力与进食相关任务相结合的实验通常被用作其他行为（如焦虑）的检测指标。性别、发情周期、昼夜节律、热量限制、美味饮食、体重增加以及压力源的特性同样影响人类和啮齿动物模型的进食行为。然而，大多数啮齿动物研究没有使用与研究人类进食行为最相关的条件。这篇综述提出了一个概念框架，用于纳入这些影响，以开发可重复且具有转化相关性的实验来研究压力对食物摄入的影响。这样的范式有可能揭示情绪化进食与肥胖之间的联系，以及与进食障碍的病因之间的联系。
Stress often affects eating behaviors, but it leads to increases in some individuals and decreases in others. Identifying physiological and psychological factors that determine the direction of eating responses to stress has been a major goal of epidemiological and clinical studies. However, challenges of standardizing the stress exposure in humans hinder efforts to uncover the underlying mechanisms. The issue of what determines the direction of stress-induced feeding responses has not been directly addressed in animal models, but assays that combine stress with a feeding-related task are commonly used as readouts of other behaviors, such as anxiety. Sex, estrous cyclicity, circadian cyclicity, caloric restriction, palatable diets, elevated body weight and properties of the stressor(s) similarly influence feeding behavior in humans and rodent models. Yet, most rodent studies do not use conditions that are most relevant for studying feeding behavior in humans. This review proposes a conceptual framework for incorporating these influences to develop reproducible and translationally relevant assays to study effects of stress on food intake. Such paradigms have the potential to uncover links between emotional eating and obesity, as well as to the etiology of eating disorders.
登录
查看更多内容
影响因子：
3
作者：
Barfield ET;Moser VA;Hand A;Grisel JE
通讯作者：
Grisel JE
DOI：
10.1038/s41386-020-0781-1
发表时间：
2021-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Alonso-Caraballo Y;Fetterly TL;Jorgensen ET;Nieto AM;Brown TE;Ferrario CR
通讯作者：
Ferrario CR
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
2.5
作者：
Anversa, Roberta G.;Campbell, Erin J.;Brown, Robyn M.
通讯作者：
Brown, Robyn M.
影响因子：
4.7
作者：
Åkerstedt, T;Knutsson, A;Kecklund, G
通讯作者：
Kecklund, G