β-endorphin modulates the effect of stress on novelty-suppressed feeding.
β-endorphin modulates the effect of stress on novelty-suppressed feeding.
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DOI：
10.3389/fnbeh.2013.00019
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发表时间：
2013
影响因子：
3
通讯作者：
Grisel JE
中科院分区：
文献类型：
--
作者：
Barfield ET;Moser VA;Hand A;Grisel JE
虽然压力与情绪和焦虑症的病理生理学有关，但并不是所有遭受压力生活事件的人都会发展为精神病理学。对应激的不同易感性可能受到遗传介导的下丘脑-垂体-肾上腺（HPA）轴活性差异和阿片肽β-内啡肽（β-E）对应激反应的调节作用的影响。本研究通过检测具有不同β-E合成能力的转基因小鼠[B6.129S2-Pomctm 1 Low/J;通过在阿黑皮素原（POMC）基因的一个或两个拷贝中插入提前终止密码子来调节]的焦虑行为，在正常条件下和3分钟强迫游泳（FS）后，研究了应对行为的遗传贡献。在这种应激暴露或对照操作后10分钟，对急性食物剥夺的雌性和雄性转基因小鼠进行新颖性抑制喂养（NSF）测试，在此期间测量它们与位于开放视野箱中心的杏仁片的相互作用。基因型和应激之间存在相互作用，即接近杏仁的潜伏期和是否接近杏仁，因此β-E水平低或缺乏的小鼠在应激暴露后表现出比正常水平的小鼠更强烈的厌恶新奇进食。这些数据为β-E对应激行为反应的调节作用提供了证据。当小鼠在行为评估之前受到压力时，焦虑行为的基因型差异出现，表明β-E在应对行为中起作用。这些发现表明，β-E系统对压力的敏感性的遗传变异可能至少部分地导致了压力反应性的遗传差异以及对压力相关精神病理学的脆弱性。
Although stress is implicated in the pathophysiology of mood and anxiety disorders, not all individuals who suffer stressful life events develop psychopathology. Differential susceptibility to stress may be influenced by genetically mediated differences in hypothalamic-pituitary-adrenal (HPA) axis activity and moderation of the stress response by the opioid peptide β-endorphin (β-E). The present study investigated genetic contributions to coping behavior by examining anxious behavior of transgenic mice with varying capacities to synthesize β-E [B6.129S2-Pomctm1Low/J; regulated by insertion of a premature stop codon into one or both copies of the proopiomelanocortin (POMC) gene], both under normal conditions and following 3 min of forced swim (FS). Ten minutes after this stress exposure or a control manipulation, acutely food-deprived female and male transgenic mice were subjected to a novelty-suppressed feeding (NSF) test, during which their interaction with an almond slice located in the center of an open field box was measured. There was an interaction between genotype and stress for latency to approach the almond and whether or not the almond was approached, such that mice with low or absent β-E displayed a stronger aversion to novelty-feeding after stress exposure than did mice with normal levels. These data provide evidence for a moderating effect of β-E on the behavioral response to stress. Genotypic differences in anxious behavior emerged when mice were stressed prior to behavioral assessment, suggesting that β-E plays a role in coping behavior. These findings indicate that genetic variability in sensitivity of the β-E system to stress may contribute, at least in part, to heritable differences in stress reactivity as well as vulnerability to stress-related psychopathology.
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影响因子：
3.4
作者：
Grisel, Judith E.;Bartels, Jessica L.;Allen, Stephani A.;Turgeon, Victoria L.
通讯作者：
Turgeon, Victoria L.
影响因子：
3.7
作者：
Castro, Jorge E.;Diessler, Shanaz;Sandi, Carmen
通讯作者：
Sandi, Carmen
影响因子：
6.7
作者：
Carroll, B. J.;Cassidy, F.;Veldhuis, J. D.
通讯作者：
Veldhuis, J. D.
影响因子：
3.6
作者：
BRITTON, DR;BRITTON, KT
通讯作者：
BRITTON, KT
影响因子：
5.8
作者：
Federenko, IS;Nagamine, M;Wüst, S
通讯作者：
Wüst, S