Dietary and stored iron as predictors of breast cancer risk: A nested case-control study in Shanghai.
Dietary and stored iron as predictors of breast cancer risk: A nested case-control study in Shanghai.
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DOI：
10.1002/ijc.24404
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发表时间：
2009-09-01
影响因子：
6.4
通讯作者：
Thomas DB
中科院分区：
文献类型：
--
作者：
Moore AB;Shannon J;Chen C;Lampe JW;Ray RM;Lewis SK;Lin M;Stalsberg H;Thomas DB
从中国移民到美国的连续几代人中乳腺癌风险的增加以及中国社会和经济变化后发病率的快速时间变化清楚地表明环境因素与这种疾病的病因有关。病例对照研究和队列研究提供的证据表明，这些因素中至少有一些可能是饮食。铁是细胞功能所必需的基本元素，也已被证明具有潜在的致癌和共致癌活性。在美国，以前不常见的铁过量已经比缺铁更常见，并且在中国可能会随着肉类消费的急剧增加而增加。在中国上海的一个妇女队列中进行了一项病例对照研究，以评估增殖性和非增殖性纤维囊性变化以及乳腺癌与膳食铁摄入量和血浆铁蛋白水平之间的可能关联。比较了346名纤维囊性病变妇女、248名乳腺癌患者和1,040名对照者的血浆铁蛋白水平和报告的膳食铁摄入量。铁蛋白水平升高与非增殖性纤维囊性变风险升高显著相关（OR：2.51，95% CI：1.16-5.45，p趋势= 0.04）。在增殖性变化和乳腺癌中观察到类似但较弱的趋势。乳腺癌风险相对于纤维囊性变化的风险与非增殖性纤维囊性变化女性的膳食铁摄入量相关（OR：2.63，95%CI：1.04-6.68，p = 0.02）。总之，这项研究发现铁（储存和饮食）与纤维囊性疾病和乳腺癌之间存在显着关联。
Increases in risk of breast cancer in successive generations of migrants to the United States from China and rapid temporal changes in incidence rates in China following social and economic changes clearly implicate environmental factors in the etiology of this disease. Case–control and cohort studies have provided evidence that at least some of these factors may be dietary. Iron, an essential element necessary for cell function, has also been demonstrated to have potential carcinogenic and co-carcinogenic activities. Iron overload, which was previously uncommon, has become more common in the United States than iron deficiency and may be increasing in China concurrently with dramatic increases in meat consumption. A case–control study nested in a cohort of women in Shanghai, China, was conducted to evaluate possible associations between risk of proliferative and nonproliferative fibrocystic changes as well as breast cancer and dietary iron intake and plasma ferritin levels. Plasma ferritin levels and reported dietary iron intake were compared in 346 women with fibrocystic changes, 248 breast cancer cases and 1,040 controls. Increasing ferritin levels were significantly associated with increasing risk of nonproliferative fibrocystic changes (OR: 2.51, 95% CI: 1.16–5.45, p trend = 0.04). Similar, but weaker, trends were observed for proliferative changes and for breast cancer. Risk of breast cancer relative to the risk of fibrocystic changes was associated with dietary iron intake in women with nonproliferative fibrocystic changes (OR: 2.63, 95% CI: 1.04–6.68, p = 0.02). In conclusion, this study finds significant associations between iron (stored and dietary) and fibrocystic disease and breast cancer.
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DOI：
10.1111/j.1349-7006.1994.tb02398.x
发表时间：
1994-06-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
GUO, WD;CHOW, WH;BLOT, WJ
通讯作者：
BLOT, WJ
影响因子：
2.9
作者：
Adzersen, KH;Jess, P;Bastert, G
通讯作者：
Bastert, G
影响因子：
6.4
作者：
KNEKT, P;REUNANEN, A;HAKULINEN, T
通讯作者：
HAKULINEN, T
影响因子：
3.7
作者：
Kulp, KS;Green, SL;Vulliet, PR
通讯作者：
Vulliet, PR
影响因子：
3.8
作者：
Baer, HJ;Schnitt, SJ;Colditz, GA
通讯作者：
Colditz, GA