Age-related neurochemical changes in the rhesus macaque inferior colliculus.
Age-related neurochemical changes in the rhesus macaque inferior colliculus.
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DOI：
10.3389/fnagi.2014.00073
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发表时间：
2014
影响因子：
4.8
通讯作者：
Recanzone GH
中科院分区：
文献类型：
--
作者：
Engle JR;Gray DT;Turner H;Udell JB;Recanzone GH
听觉相关性听力损失（ARHL）的特点是听力测定听力缺陷，沿听觉通路传播沿着。神经化学物质的变化作为一个功能的老化也被确定在神经元沿着听觉通路在啮齿动物和食肉动物，然而，很少有人知道这些神经化学物质如何在非人类灵长类动物的变化。为了研究这些代偿性神经化学变化如何与正常衰老和听力敏感性沿着听觉通路相关，我们收集了7只年龄从15岁到35岁的恒河猴的听觉脑干反应（ABR）和脑标本，并检测短声诱发ABR阈值与ABR诱发纯音平均值（PTA）的关系，以及小白蛋白和NADPH-黄递酶阳性细胞位于听中脑。结果发现，下丘中央核和周围皮质区的小白蛋白阳性细胞数与年龄和ABR PTA密切相关。我们还发现，NADPHd阳性细胞在这些相同的区域的数量与正常老化或ABR阈值的变化无关。这些研究结果表明，听觉中脑经历了小白蛋白表达神经元的上调与老化，这是在整个听力范围内的频率处理的变化。
Age-related hearing loss (ARHL) is marked by audiometric hearing deficits that propagate along the auditory pathway. Neurochemical changes as a function of aging have also been identified in neurons along the auditory pathway in both rodents and carnivores, however, very little is known about how these neurochemicals change in the non-human primate. To examine how these compensatory neurochemical changes relate to normal aging and audiometric sensitivity along the auditory pathway, we collected auditory brainstem responses (ABRs) and brain specimens from seven rhesus monkeys spanning in age from 15 to 35 years old, and examined the relationship between click evoked ABR thresholds and the ABR evoked pure tone average (PTA) and changes in the number of parvalbumin and NADPH-diaphorase positive cells in the auditory midbrain. We found that the number of parvalbumin positive cells in the central nucleus and the surrounding cortex regions of the inferior colliculus were strongly correlated with advancing age and ABR PTA. We also found that the numbers of NADPHd positive cells in these same regions were not associated with normal aging or changes in the ABR thresholds. These findings suggest that the auditory midbrain undergoes an up-regulation of parvalbumin expressing neurons with aging that is related to changes in the processing of frequencies across the audiometric range.
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影响因子：
1.9
作者：
BENNETT, CL;DAVIS, RT;MILLER, JM
通讯作者：
MILLER, JM
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH
影响因子：
16.2
作者：
BREDT, DS;GLATT, CE;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
3.3
作者：
Caspary, DM;Holder, TM;Naritoku, DK
通讯作者：
Naritoku, DK
影响因子：
2.8
作者：
Fowler, Cynthia G.;Chiasson, Kirstin Beach;Leslie, Tami Hanson;Thomas, Denise;Beasley, T. Mark;Kemnitz, Joseph W.;Weindruch, Richard
通讯作者：
Weindruch, Richard