miRNAs in decidual NK cells: regulators worthy of attention during pregnancy.
miRNAs in decidual NK cells: regulators worthy of attention during pregnancy.
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DOI：
10.1186/s12958-021-00812-2
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发表时间：
2021-10-02
期刊：
影响因子：
--
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Li L;Feng T;Zhou W;Liu Y;Li H
T、B、自然杀伤细胞、树突状细胞和巨噬细胞等重要免疫效应细胞参与调节孕期免疫反应。在这些免疫细胞中，蜕膜NK(DNK)细胞参与了母胎界面的关键胎盘发育过程，如子宫螺旋动脉重塑、滋养层侵袭和蜕膜化。从机制上讲，DNK细胞通过分泌细胞因子、趋化因子和血管生成介质，以及它们与滋养层细胞和其他蜕膜细胞的相互作用，显著影响妊娠结局。MicroRNAs(MiRNAs)是一种非编码的小RNA分子，参与人类疾病的发生和发展。虽然对循环中miRNAs在病理机制中的作用已经进行了广泛的研究，但关于miRNAs在NK细胞，尤其是DNK细胞中的调节作用的报道还很少。在这篇综述中，我们分析了miRNA对DNK细胞功能的调节在妊娠期间对免疫系统的影响。我们讨论了某些miRNAs在DNK细胞中的异常表达，这些表达可能导致病理后果，如复发性妊娠丢失(RPL)。有趣的是，在妊娠早期和晚期，DNK细胞和外周血自然杀伤(PNK)细胞以及PNK细胞的miRNA表达模式也不同。MiRNA的失调在驱动DNK和PNK细胞的免疫功能中起着关键的调节作用。进一步了解DNK细胞中miRNAs的分子机制可能会为预防妊娠失败的治疗方法的发展提供新的见解。
The critical immune effectors, including T, B, and natural killer (NK) cells, dendritic cells, and macrophages participate in regulating immune responses during pregnancy. Among these immune cells, decidual NK (dNK) cells are involved in key placental development processes at the maternal–fetal interface, such as uterine spiral artery remodeling, trophoblast invasion, and decidualization. Mechanistically, dNK cells significantly influence pregnancy outcome by secreting cytokines, chemokines, and angiogenic mediators and by their interactions with trophoblasts and other decidual cells. MicroRNAs (miRNAs) are small non-coding RNA molecules that participate in the initiation and progression of human diseases. Although the functions of circulating miRNAs in pathological mechanism has been extensively studied, the regulatory roles of miRNAs in NK cells, especially in dNK cells, have been rarely reported. In this review, we analyze the effects of miRNA regulations of dNK cell functions on the immune system during gestation. We discuss aberrant expressions of certain miRNAs in dNK cells that may lead to pathological consequences, such as recurrent pregnancy loss (RPL). Interestingly, miRNA expression patterns are also different between dNK cells and peripheral NK (pNK) cells, and pNK cells in the first- and third‐trimester of gestation. The dysregulation of miRNA plays a pivotal regulatory role in driving immune functions of dNK and pNK cells. Further understanding of the molecular mechanisms of miRNAs in dNK cells may provide new insights into the development of therapeutics to prevent pregnancy failure.
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