Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.
Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.
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基于规则的多细胞生物系统模拟 - 建模技术的回顾。
DOI：
10.1007/s12195-009-0078-2
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发表时间：
2009-09
影响因子：
2.8
通讯作者：
Tran-Son-Tay, Roger
中科院分区：
文献类型：
--
作者：
Hwang, Minki;Garbey, Marc;Berceli, Scott A.;Tran-Son-Tay, Roger
多细胞生物系统（MCBS）的涌现行为是由单个细胞的行为及其与其他细胞和环境的相互作用引起的。对MCBS建模需要将这些复杂的相互作用纳入单个细胞和环境之间。MCBS的建模方法可以分为两类：连续体模型和基于细胞的模型。连续体模型通常采用偏微分方程的形式，模型方程提供了对系统中组件之间关系的洞察。基于细胞的模型模拟每个单独的细胞行为和它们之间的相互作用，从而能够观察紧急系统行为。本文重点介绍了MCBS的单元模型，特别是基于规则的MCBS仿真方法的技术方面。讨论了如何在计算域中实现细胞行为以及与其他细胞和环境的交互。本文综述了细胞的分裂、迁移、凋亡/坏死和分化等行为。环境因素，如细胞外基质，化学品，微血管，和力量也进行了讨论。这些细胞的行为和相互作用的应用实例。
Emergent behaviors of multi-cellular biological systems (MCBS) result from the behaviors of each individual cells and their interactions with other cells and with the environment. Modeling MCBS requires incorporating these complex interactions among the individual cells and the environment. Modeling approaches for MCBS can be grouped into two categories: continuum models and cell-based models. Continuum models usually take the form of partial differential equations, and the model equations provide insight into the relationship among the components in the system. Cell-based models simulate each individual cell behavior and interactions among them enabling the observation of the emergent system behavior. This review focuses on the cell-based models of MCBS, and especially, the technical aspect of the rule-based simulation method for MCBS is reviewed. How to implement the cell behaviors and the interactions with other cells and with the environment into the computational domain is discussed. The cell behaviors reviewed in this paper are division, migration, apoptosis/necrosis, and differentiation. The environmental factors such as extracellular matrix, chemicals, microvasculature, and forces are also discussed. Application examples of these cell behaviors and interactions are presented.
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