FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China.
FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China.
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FBXW7基因多态性与中国新疆维吾尔族人群2型糖尿病相关
DOI：
10.1186/s41065-021-00191-z
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发表时间：
2021-08-09
期刊：
影响因子：
2.7
通讯作者：
Ma YT
中科院分区：
文献类型：
--
作者：
Yan SQ;Adi D;Liu C;Wang MM;Abuzhalihana J;Wu Y;Fu ZY;Yang YN;Li XM;Xie X;Liu F;Chen BD;Ma YT
背景fbxw7基因表达与糖脂代谢呈正相关，在动物模型中与糖尿病相关。在目前的研究中，我们主要探讨FBXW7基因的遗传变异是否与中国新疆维吾尔族2型糖尿病（T2DM）相关，以及T2DM的危险因素。方法选取2164名中国维吾尔族受试者（T2DM患者673例，对照组1491例），采用改进的多重结扎检测反应（iMLDR）技术对FBXW7基因的4个snp位点（rs10033601、rs2255137、rs2292743和rs35311955）进行分型。结果2型糖尿病患者rs10033601基因型（GA vs AA + GG）和rs2292743基因型（TA vs TT + AA）与对照组基因型差异有统计学意义（P= 0.005和P= 0.012）。多因素混杂校正后，rs10033601和rs2292743 snp仍是T2DM的独立危险因素[GA vs AA + GG：优势比= 1.35,95%可信区间(CI) = 1.12-1.64，P= 0.002；助教和TT + AA: = 1.28, 95% CI -1.55 = 1.06, P = 0.011)。具有GA基因型rs10033601和TA基因型rs2292743的中国维吾尔族人群参与者与血糖水平显著升高相关。结论FBXW7基因rs10033601和rs2292743与新疆维吾尔族人群T2DM相关。
BackgroundFBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors for T2DM in Uygur people in Xinjiang, China.MethodsA total of 2164 Chinese Uygur subjects (673 T2DM patients and 1491 controls) were recruited for our case–control study, and four SNPs (rs10033601, rs2255137, rs2292743 and rs35311955) of the FBXW7 gene were genotyped using the improved multiplex ligation detection reaction (iMLDR) technique.ResultsOur study showed that the genotypes using the overdominant model (GA vs AA + GG) of rs10033601 and using the overdominant model (TA vs TT + AA) of rs2292743 were significantly different between T2DM patients and the controls (P= 0.005 andP= 0.012, respectively). After multivariate adjustments for confounders, the rs10033601 and rs2292743 SNPs were still independent risk factors for T2DM [GA vs AA + GG: odds ratio = 1.35, 95% confidence interval (CI) = 1.12–1.64,P= 0.002; TA vs TT + AA: OR = 1.28, 95% CI = 1.06–1.55,P= 0.011]. Participants within the Chinese Uygur populations and who with the GA genotype of rs10033601 and the TA genotype of rs2292743 were associated with significantly elevated glucose levels.ConclusionsOur study revealed that both rs10033601 and rs2292743 of the FBXW7 gene were associated with T2DM in the Uygur populations in Xinjiang.
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DOI：
10.22088/acadpub.bums.6.3.135
发表时间：
2017
影响因子：
--
作者：
Tabatabaei-Malazy O;Khodaeian M;Bitarafan F;Larijani B;M Amoli M
通讯作者：
M Amoli M
影响因子：
29
作者：
Sundqvist, A;Bengoechea-Alonso, MT;Ericsson, J
通讯作者：
Ericsson, J
影响因子：
56.9
作者：
Nateri, AS;Riera-Sans, L;Behrens, A
通讯作者：
Behrens, A
影响因子：
4.8
作者：
Hirano, Y;Yoshida, M;Sato, R
通讯作者：
Sato, R
影响因子：
16.2
作者：
Vijayakumar P;Nelson RG;Hanson RL;Knowler WC;Sinha M
通讯作者：
Sinha M