Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG
Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG
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硫唑嘌呤治疗一例 MOG-IgG 血清阳性的儿童多发性硬化症病例
DOI：
10.1016/j.jocn.2016.12.022
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发表时间：
2017-04
影响因子：
2
通讯作者：
Qiu W
中科院分区：
文献类型：
--
作者：
Zhou Yifan;Huang Qiao;Lu Tingting;Sun Xiaobo;Fang Ling;Lu Zhengqi;Hu Xueqiang;Qiu Wei;Huang Qiao;Kermode Allan;Kermode Allan;Qiu W
儿童多发性硬化症(PedMS)的治疗缺乏证据。使用硫唑嘌呤治疗PedMS尚未见报道。对1例髓鞘少突胶质细胞糖蛋白(MOG)-Ig G抗体阳性的10岁多发性硬化症患儿进行硫唑嘌呤联合口服甲基强的松龙治疗。患者表现出临床和磁共振成像的稳定性，有MOG-IgG血清转换。在5年的时间里，没有出现重大的副作用。硫唑嘌呤可能是一种治疗选择，特别是在医疗资源贫乏的地区，对于MOG-IgG血清阳性的多发性硬化症儿童患者。
There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.
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影响因子：
4.4
作者：
S. Tenembaum
通讯作者：
S. Tenembaum
影响因子：
1.9
作者：
Julian L;Serafin D;Charvet L;Ackerson J;Benedict R;Braaten E;Brown T;O'Donnell E;Parrish J;Preston T;Zaccariello M;Belman A;Chitnis T;Gorman M;Ness J;Patterson M;Rodriguez M;Waubant E;Weinstock-Guttman B;Yeh A;Krupp LB;Network of Pediatric MS Centers of Excellence
通讯作者：
Network of Pediatric MS Centers of Excellence
影响因子：
2
作者：
M. Simone;T. Chitnis
通讯作者：
M. Simone;T. Chitnis
DOI：
10.1177/1352458514527862
发表时间：
2014-10
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Charvet LE;O'Donnell EH;Belman AL;Chitnis T;Ness JM;Parrish J;Patterson M;Rodriguez M;Waubant E;Weinstock-Guttman B;Krupp LB;US Network of Pediatric MS Centers
通讯作者：
US Network of Pediatric MS Centers
影响因子：
6
作者：
J. Salzer;J. Lycke;R. Wickström;H. Naver;F. Piehl;A. Svenningsson
通讯作者：
J. Salzer;J. Lycke;R. Wickström;H. Naver;F. Piehl;A. Svenningsson