A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children.
A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children.
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DOI：
10.1186/1742-2094-9-54
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发表时间：
2012-03-16
影响因子：
9.3
通讯作者：
Mostafa GA
中科院分区：
文献类型：
--
作者：
Al-Ayadhi LY;Mostafa GA
S100B是一种钙结合蛋白，主要由星形胶质细胞产生。血清S100B蛋白水平升高反映了神经损伤。自身免疫可能在某些患者的自闭症发病机制中起一定作用。自身抗体可能会穿过血脑屏障，与脑组织抗原结合，形成免疫复合体，导致神经损伤。我们首次研究了孤独症儿童血清神经元损伤标志物S100B蛋白水平与抗核糖体P蛋白抗体之间的关系。检测了孤独症儿童血清S100B蛋白和抗核糖体P抗体，并与46例健康儿童作了比较。孤独症儿童血清S100B蛋白水平显著高于健康对照组(P<；0.001)。重度孤独症患儿血清S100B蛋白水平显著高于轻、中度孤独症患儿(P=0.01)。40.6%的自闭症儿童血清抗核糖体P抗体水平升高。血清S100B蛋白水平与抗核糖体P抗体水平无显著相关性(P=0.29)。S100B蛋白水平在自闭症儿童中升高，并与自闭症严重程度显著相关。这可能表明自闭症患者存在潜在的神经病理状况。抗核糖体P抗体可能不是导致某些自闭症儿童血清S100B蛋白水平升高的可能因素。然而，有必要进一步研究血清S100B蛋白水平与其他自身抗体之间的可能联系，这些抗体可能是自闭症患者中枢神经系统自身免疫的指标。
S100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage. Autoimmunity may have a role in the pathogenesis of autism in some patients. Autoantibodies may cross the blood-brain barrier and combine with brain tissue antigens, forming immune complexes and resulting in neurological damage. We are the first to investigate the relationship between serum levels of S100B protein, a marker of neuronal damage, and antiribosomal P protein antibodies in autistic children. Serum S100B protein and antiribosomal P antibodies were measured in 64 autistic children in comparison to 46 matched healthy children. Autistic children had significantly higher serum S100B protein levels than healthy controls (P < 0.001). Children with severe autism had significantly higher serum S100B protein than patients with mild to moderate autism (P = 0.01). Increased serum levels of antiribosomal P antibodies were found in 40.6% of autistic children. There were no significant correlations between serum levels of S100B protein and antiribosomal P antibodies (P = 0.29). S100B protein levels were elevated in autistic children and significantly correlated to autistic severity. This may indicate the presence of an underlying neuropathological condition in autistic patients. Antiribosomal P antibodies may not be a possible contributing factor to the elevated serum levels of S100B protein in some autistic children. However, further research is warranted to investigate the possible link between serum S100B protein levels and other autoantibodies, which are possible indicators of autoimmunity to central nervous system in autism.
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影响因子：
2.2
作者：
Green, AJE;Keir, G;Thompson, EJ
通讯作者：
Thompson, EJ
影响因子：
6.2
作者：
Kanner, AA;Marchi, N;Janigro, D
通讯作者：
Janigro, D
影响因子：
2.6
作者：
Biberthaler, P;Mussack, T;Jochum, M
通讯作者：
Jochum, M
影响因子：
4.4
作者：
MICHETTI, F;MASSARO, A;RIGON, G
通讯作者：
RIGON, G
影响因子：
15.1
作者：
AL-ayadhi, Laila Y.;Mostafa, Gehan A.
通讯作者：
Mostafa, Gehan A.