Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root.
Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root.
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DOI：
10.1371/journal.pone.0194384
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Obrist D
中科院分区：
文献类型：
--
作者：
Hasler D;Obrist D
经过人工主动脉瓣的流场包括许多指示人工瓣膜是否功能良好的细节。然而，尚未完全理解最佳流动方案的外观，即适当的流体动力学的哪些细微之处对于人工瓣膜的耐久性和兼容性至关重要。在这项研究中，我们测量和分析了主动脉根部尺寸的生物心脏瓣膜附近的三维流场。测量在不同尺寸的主动脉根部体模内进行，安装在定制的液压装置中，其模拟主动脉中的生理流动条件。采用层析粒子图像测速技术对不同工况下的三维瞬时速度场进行了测量。分析和比较了几个3D场（例如瞬时和平均速度、3D剪切率），重点关注主动脉根部尺寸的影响，同时也是为了获得通过生物瓣膜的3D流动结构的一般见解。我们发现，主动脉射流的直径相对于升主动脉的直径是确定血流特性的最重要参数。相对于主动脉射流的横截面，大的主动脉横截面与升主动脉中较高水平的湍流强度和较高的逆行流相关。
The flow field past a prosthetic aortic valve comprises many details that indicate whether the prosthesis is functioning well or not. It is, however, not yet fully understood how an optimal flow scenario would look, i.e. which subtleties of the fluid dynamics in place are essential regarding the durability and compatibility of a prosthetic valve. In this study, we measured and analyzed the 3D flow field in the vicinity of a bio-prosthetic heart valve in function of the aortic root size. The measurements were conducted within aortic root phantoms of different size, mounted in a custom-built hydraulic setup, which mimicked physiological flow conditions in the aorta. Tomographic particle image velocimetry was used to measure the 3D instantaneous velocity field at various instances. Several 3D fields (e.g. instantaneous and mean velocity, 3D shear rate) were analyzed and compared focusing on the impact of the aortic root size, but also in order to gain general insight in the 3D flow structure past the bio-prosthetic valve. We found that the diameter of the aortic jet relative to the diameter of the ascending aorta is the most important parameter in determining the characteristics of the flow. A large aortic cross-section, relative to the cross-section of the aortic jet, was associated with higher levels of turbulence intensity and higher retrograde flow in the ascending aorta.
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