Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.
Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.
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DOI：
10.1099/mic.0.000695
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Wigneshweraraj S
中科院分区：
文献类型：
--
作者：
Krishna A;Holden MTG;Peacock SJ;Edwards AM;Wigneshweraraj S
病原体金黄色葡萄球菌的鼻腔定植是继发感染的危险因素。编码毒力调节因子RSP的基因的功能突变与金黄色葡萄球菌从定植菌株转变为引起菌血症的菌株有关。在这里，我们报告了在临床分离株中检测到的几个新的RSP活性改变突变，包括第一次发现的增强agr操纵子活性的突变。我们评估了这些突变是如何影响感染相关表型的，并发现功能突变的丢失和增强对血液中金黄色葡萄球菌的存活率和抗生素敏感性具有相反的影响。这些发现增加了越来越多的证据，表明金黄色葡萄球菌为了获得有利于宿主生存的特征而“权衡”了毒力，并表明感染的严重性和治疗方案可能会受到毒力调节因子RSP突变的显著影响。
Nasal colonization by the pathogen Staphylococcus aureus is a risk factor for subsequent infection. Loss of function mutations in the gene encoding the virulence regulator Rsp are associated with the transition of S. aureus from a colonizing isolate to one that causes bacteraemia. Here, we report the identification of several novel activity-altering mutations in rsp detected in clinical isolates, including for the first time, mutations that enhance agr operon activity. We assessed how these mutations affected infection-relevant phenotypes and found loss and enhancement of function mutations to have contrasting effects on S. aureus survival in blood and antibiotic susceptibility. These findings add to the growing body of evidence that suggests S. aureus ‘trades off’ virulence for the acquisition of traits that benefit survival in the host, and indicates that infection severity and treatment options can be significantly affected by mutations in the virulence regulator rsp.
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