Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator.
Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator.
复制标题
模拟午睡和非午睡模式对人体昼夜节律振荡器的影响。
DOI：
10.1177/07487304231180953
复制
发表时间：
2023-10
影响因子：
3.5
通讯作者：
Behn, Cecilia Diniz
中科院分区：
文献类型：
--
作者：
Stowe, Shelby R.;LeBourgeois, Monique K.;Behn, Cecilia Diniz
在幼儿期，从双相睡眠到双相睡眠-觉醒模式的巩固，即从午睡和晚上睡觉到只在晚上睡觉的过渡，代表了一个重要的发展里程碑。午睡行为的减少与昼夜节律系统的时间提前有关;然而，尚不清楚这种提前是否代表昼夜节律钟对曝光模式改变的标准反应，或者它是否还反映了发育中的昼夜节律系统的特征。使用人类昼夜节律起搏器的数学模型，我们研究了午睡和非午睡模式的光暴露对夹带的昼夜节律相位的影响。模拟光照时间表基于20名儿童（34.2 ± 2.0个月）的已发表数据，这些儿童具有习惯性午睡或非午睡睡眠模式（15名午睡者）。我们发现该模型预测了午睡和非午睡光模式的不同昼夜节律阶段：午睡期间下午光线的减少和与午睡幼儿晚些时候睡觉相关的晚间光线的增加都有助于观察到午睡和非午睡光时间表之间产生的昼夜节律相位差。我们系统地量化了午睡持续时间、时间和光照强度对相移的影响，发现午睡时间越长、时间越早，相位延迟越大。此外，我们模拟的相位响应曲线，1小时的光脉冲和1小时的暗脉冲预测的相位和强度的依赖性，这些变化的曝光。我们发现，与暗脉冲相比，光脉冲产生了更大的位移，我们分析了模型动力学，以确定导致这种不对称性的特征。这些研究结果表明，午睡状态影响昼夜节律的时间，由于改变模式的光暴露，与动态的生物钟和光处理介导的影响与白天午睡相关的黑暗脉冲。
In early childhood, consolidation of sleep from a biphasic to a monophasic sleep-wake pattern, that is, the transition from sleeping during an afternoon nap and at night to sleeping only during the night, represents a major developmental milestone. Reduced napping behavior is associated with an advance in the timing of the circadian system; however, it is unknown if this advance represents a standard response of the circadian clock to altered patterns of light exposure or if it additionally reflects features of the developing circadian system. Using a mathematical model of the human circadian pacemaker, we investigated the impact of napping and non-napping patterns of light exposure on entrained circadian phases. Simulated light schedules were based on published data from 20 children (34.2 ± 2.0 months) with habitual napping or non-napping sleep patterns (15 nappers). We found the model predicted different circadian phases for napping and non-napping light patterns: both the decrease in afternoon light during the nap and the increase in evening light associated with napping toddlers’ later bedtimes contributed to the observed circadian phase difference produced between napping and non-napping light schedules. We systematically quantified the effects on phase shifting of nap duration, timing, and light intensity, finding larger phase delays occurred for longer and earlier naps. In addition, we simulated phase response curves to a 1-h light pulse and 1-h dark pulse to predict phase and intensity dependence of these changes in light exposure. We found the light pulse produced larger shifts compared with the dark pulse, and we analyzed the model dynamics to identify the features contributing to this asymmetry. These findings suggest that napping status affects circadian timing due to altered patterns of light exposure, with the dynamics of the circadian clock and light processing mediating the effects of the dark pulse associated with a daytime nap.
登录
查看更多内容
影响因子：
2.5
作者：
Akacem LD;Wright KP Jr;LeBourgeois MK
通讯作者：
LeBourgeois MK
影响因子：
--
作者：
Akacem, Lameese D.;Wright, Kenneth P., Jr.;LeBourgeois, Monique K.
通讯作者：
LeBourgeois, Monique K.
影响因子：
9.9
作者：
通讯作者：
--
影响因子：
--
作者：
DAAN, S;BEERSMA, DGM;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
3.7
作者：
Crowley, Stephanie J.;Van Reen, Eliza;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.