Clostridium difficile infection: update on emerging antibiotic treatment options and antibiotic resistance.
Clostridium difficile infection: update on emerging antibiotic treatment options and antibiotic resistance.
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DOI：
10.1586/eri.10.28
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发表时间：
2010-05
影响因子：
5.7
通讯作者：
Garey KW
中科院分区：
文献类型：
--
作者：
Shah D;Dang MD;Hasbun R;Koo HL;Jiang ZD;DuPont HL;Garey KW
艰难梭菌感染（CDI）是住院患者明显腹泻的最常见原因。 CDI 的发生率和严重程度正在增加。该疾病发病率和严重程度的增加引发了人们对 CDI 最佳治疗以及新疗法和药物发现的兴趣。目前的治疗策略是不够的，甲硝唑的反应率降低，并且使用甲硝唑和口服万古霉素的复发率高。尽管发病率仍然较低，但已注意到用于治疗 CDI 的抗生素的体外耐药性。最近，关于新的抗C的重要数据出现了。艰难梭菌抗生素，例如利福昔明、利福拉齐、非达霉素、硝唑尼特、替加环素和雷莫拉宁。本次综述的目的是提供 CDI 体外敏感性和新抗生素治疗方案的最新信息。本综述将主要关注过去 36 个月内发表的科学研究，以便提供有关该主题的最新综述。
Clostridium difficile infection (CDI) is the most common cause of identifiable diarrhea in hospitalized patients. The incidence and severity of CDIs are increasing. The increased incidence and severity of the disease has sparked interest in the optimal treatment of CDI as well as the use of new therapies and drug discovery. Current treatment strategies are inadequate with decreased response rates to metronidazole, and high recurrence rates with the use of metronidazole and oral vancomycin. Although incidence rates continue to be low, in vitro resistance to antibiotics used for the treatment of CDI has been noted. Recently, important data has emerged on new anti-C. difficile antibiotics such as rifaximin, rifalazil, fidaxomicin, nitazoxanide, tigecycline and ramoplanin. The purpose of this review is to provide an update on the in vitro susceptibility and new antibiotic treatment options for CDI. This review will focus primarily on scientific studies published in the last 36 months in order to provide an up-to-date review on the topic.
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