Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy.
Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy.
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DOI：
10.1038/srep05080
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发表时间：
2014-05-30
影响因子：
4.6
通讯作者：
Cai W
中科院分区：
文献类型：
--
作者：
Chen F;Hong H;Shi S;Goel S;Valdovinos HF;Hernandez R;Theuer CP;Barnhart TE;Cai W
中空介孔二氧化硅纳米颗粒（HMSN）最近因其作为癌症成像和治疗的有吸引力的纳米平台的巨大潜力而引起了越来越多的兴趣。然而，可能由于缺乏有效的体内靶向策略和成熟的表面工程技术，迄今为止尚未实现用于体内活性肿瘤靶向、定量肿瘤摄取评估、多模态成像、生物分布和增强药物递送的HMSN工程。在这里，我们报告了体内肿瘤靶向正电子发射断层扫描（PET）/近红外荧光（NIRF）双模态成像以及使用普遍适用的表面工程技术增强的 HMSN 药物输送。已经进行了系统的体外和体内研究，以研究功能良好的 HMSN 纳米缀合物的稳定性、肿瘤靶向功效和特异性、生物分布和药物递送能力。在 4T1 小鼠乳腺癌模型中，TRC105（与肿瘤新血管系统上的 CD105 结合）结合的 HMSN 的最高摄取量约为 10%ID/g，比非靶向组高 3 倍，这使得表面工程 HMSN 成为未来癌症治疗诊断学中极具吸引力的药物输送纳米平台。
Hollow mesoporous silica nanoparticle (HMSN) has recently gained increasing interests due to their tremendous potential as an attractive nano-platform for cancer imaging and therapy. However, possibly due to the lack of efficient in vivo targeting strategy and well-developed surface engineering techniques, engineering of HMSN for in vivo active tumor targeting, quantitative tumor uptake assessment, multimodality imaging, biodistribution and enhanced drug delivery have not been achieved to date. Here, we report the in vivo tumor targeted positron emission tomography (PET)/near-infrared fluorescence (NIRF) dual-modality imaging and enhanced drug delivery of HMSN using a generally applicable surface engineering technique. Systematic in vitro and in vivo studies have been performed to investigate the stability, tumor targeting efficacy and specificity, biodistribution and drug delivery capability of well-functionalized HMSN nano-conjugates. The highest uptake of TRC105 (which binds to CD105 on tumor neovasculature) conjugated HMSN in the 4T1 murine breast cancer model was ~10%ID/g, 3 times higher than that of the non-targeted group, making surface engineered HMSN a highly attractive drug delivery nano-platform for future cancer theranostics.
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影响因子：
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作者：
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