In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study.
In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study.
复制标题
DOI：
10.1093/ofid/ofab233
复制
发表时间：
2021-06
影响因子：
4.2
通讯作者：
Diefenbach MA
中科院分区：
文献类型：
--
作者：
Richardson S;Gitlin J;Kozel Z;Levy S;Rahman H;Hirsch JS;McGinn T;Diefenbach MA
我们的目标是描述2019年住院的年轻成人冠状病毒病患者(新冠肺炎)的特征，并确定30天内存活的预测因素。这项回顾性队列研究在纽约市地区的12家急性护理医院进行。这项研究包括2020年3月1日至4月27日期间住院的18-39岁确诊为新冠肺炎的患者。人口统计、临床和结果数据从电子健康记录报告中提取。共有1013名患者参加了这项研究(中位年龄33岁；四分位数范围[IQR]28-36；52%女性)。在研究结束时，940名患者(92.8%)活着出院，18名(1.8%)仍在住院，5名(0.5%)被转移到另一家急性护理机构，50名(4.9%)死亡。住院年轻患者中最常见的并发症是肥胖(51.2%)、糖尿病(14.8%)和高血压(13%)。多变量分析显示肥胖(调整后的危险比[AHR]，2.71；95%可信区间[CI]，1.28-5.73；P=.002)和Charlson共病指数评分(AHR，1.20；95%CI，1.07-1.35；P=.002)是住院30天死亡率的独立预测因素。肥胖被认为是新冠肺炎患者30天住院生存的最强负面预测因素。在确诊为新冠肺炎的最大住院青年队列(N = 1013；18-39岁)中对生存的临床预测因素进行了检验。死亡率为5%，与合并症和肥胖显著相关。
Our objective was to characterize young adult patients hospitalized with coronavirus disease 2019 (COVID-19) and identify predictors of survival at 30 days. This retrospective cohort study took place at 12 acute care hospitals in the New York City area. Patients aged 18–39 hospitalized with confirmed COVID-19 between March 1 and April 27, 2020 were included in the study. Demographic, clinical, and outcome data were extracted from electronic health record reports. A total of 1013 patients were included in the study (median age, 33 years; interquartile range [IQR], 28–36; 52% female). At the study end point, 940 (92.8%) patients were discharged alive, 18 (1.8%) remained hospitalized, 5 (0.5%) were transferred to another acute care facility, and 50 (4.9%) died. The most common comorbidities in hospitalized young adult patients were obesity (51.2%), diabetes mellitus (14.8%), and hypertension (13%). Multivariable analysis revealed that obesity (adjusted hazard ratio [aHR], 2.71; 95% confidence interval [CI], 1.28–5.73; P = .002) and Charlson comorbidity index score (aHR, 1.20; 95% CI, 1.07–1.35; P = .002) were independent predictors of in-hospital 30-day mortality. Obesity was identified as the strongest negative predictor of 30-day in-hospital survival in young adults with COVID-19. Clinical predictors of survival were examined among the largest cohort of hospitalized young adults (N = 1013; 18–39 years) diagnosed with COVID-19. Mortality was 5% and was significantly associated with comorbid conditions and obesity.
登录
查看更多内容
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,
DOI：
10.20452/pamw.15272
发表时间：
2020-04-30
影响因子：
4.8
作者：
Lippi, Giuseppe;Wong, Johnny;Henry, Brandon M.
通讯作者：
Henry, Brandon M.
DOI：
10.1016/0021-9681(87)90171-8
发表时间：
1987-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
CHARLSON, ME;POMPEI, P;MACKENZIE, CR
通讯作者：
MACKENZIE, CR
DOI：
10.15585/mmwr.mm6915e4
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team
影响因子：
6.9
作者：
Klang, Eyal;Kassim, Gassan;Reich, David L.
通讯作者：
Reich, David L.