The importance of mosquito behavioural adaptations to malaria control in Africa.

The importance of mosquito behavioural adaptations to malaria control in Africa.
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DOI:
10.1111/evo.12063
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发表时间:
2013-04
期刊:
Evolution; international journal of organic evolution
影响因子:
--
通讯作者:
Lindsay SW
Lindsay SW
中科院分区:
其他
文献类型:
--
作者:
Gatton ML;Chitnis N;Churcher T;Donnelly MJ;Ghani AC;Godfray HC;Gould F;Hastings I;Marshall J;Ranson H;Rowland M;Shaman J;Lindsay SW

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在过去十年中,长效驱虫蚊帐的使用,加上改进的药物疗法、室内滞留喷洒和更好的卫生基础设施,帮助许多非洲国家在一代人的时间里首次减少了疟疾。然而,病媒对杀虫剂的抗药性正在对这些成果构成威胁。我们回顾了对LLINs和IRS的行为抗性的新数据和历史数据。总的来说,目前的文献表明,行为和物种的变化可能正在出现,但数据是稀疏的,有时不令人信服。然而,初步建模表明,行为抗性可能对疟疾控制的有效性产生重大影响。我们提出了七项建议,以提高对疟疾病媒耐药性的认识。如果我们要保持在降低疟疾发病率和死亡率方面取得的重大成果,确定生理和行为杀虫剂抗药性对公共卫生的影响是一个紧迫的优先事项。
Over the past decade the use of long-lasting insecticidal nets (LLINs), in combination with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helped reduce malaria in many African countries for the first time in a generation. However, insecticide resistance in the vector is an evolving threat to these gains. We review emerging and historical data on behavioral resistance in response to LLINs and IRS. Overall the current literature suggests behavioral and species changes may be emerging, but the data are sparse and, at times unconvincing. However, preliminary modeling has demonstrated that behavioral resistance could have significant impacts on the effectiveness of malaria control. We propose seven recommendations to improve understanding of resistance in malaria vectors. Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if we are to maintain the significant gains made in reducing malaria morbidity and mortality.
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