Energy-efficient waveform shapes for neural stimulation revealed with a genetic algorithm.
Energy-efficient waveform shapes for neural stimulation revealed with a genetic algorithm.
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DOI：
10.1088/1741-2560/7/4/046009
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发表时间：
2010-08
影响因子：
4
通讯作者：
Grill WM
中科院分区：
文献类型：
--
作者：
Wongsarnpigoon A;Grill WM
刺激的能量效率是电池供电的植入式刺激器的重要考虑因素。我们使用遗传算法（GA）来确定神经刺激的能量最佳波形形状。GA耦合到哺乳动物有髓轴突的细胞外刺激的计算模型。随着GA的发展，波形变得越来越节能，并收敛到能量最优的形状。GA的结果在几次试验中是一致的，并且得到的波形类似于截断的高斯曲线。当约束到单相阴极波形，GA产生的波形是对称的峰值，这大约发生在脉冲的中间。然而，当阴极波形耦合到矩形电荷平衡阳极脉冲时，峰的位置和锐度随着持续时间和定时而变化（即，在阴极相之前或之后）。在哺乳动物轴突群体的模型和猫坐骨神经的体内实验中，GA优化的波形比神经刺激中使用的几种常规波形形状更节能和电荷效率更高。如果用于植入式神经刺激器，GA优化的波形可以延长电池寿命，从而减少充电间隔的频率，植入脉冲发生器的体积以及电池更换手术的成本和风险。
The energy efficiency of stimulation is an important consideration for battery-powered implantable stimulators. We used a genetic algorithm (GA) to determine the energy-optimal waveform shape for neural stimulation. The GA was coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. As the GA progressed, waveforms became increasingly energy-efficient and converged upon an energy-optimal shape. The results of the GA were consistent across several trials, and resulting waveforms resembled truncated Gaussian curves. When constrained to monophasic cathodic waveforms, the GA produced waveforms that were symmetric about the peak, which occurred approximately during the middle of the pulse. However, when the cathodic waveforms were coupled to rectangular charge-balancing anodic pulses, the location and sharpness of the peak varied with the duration and timing (i.e., before or after cathodic phase) of the anodic phase. In a model of a population of mammalian axons and in vivo experiments on cat sciatic nerve, the GA-optimized waveforms were more energy-efficient and charge-efficient than several conventional waveform shapes used in neural stimulation. If used in implantable neural stimulators, GA-optimized waveforms could prolong battery life, thereby reducing the frequency of recharge intervals, the volume of implanted pulse generators, and the costs and risks of battery-replacement surgeries.
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影响因子：
4.6
作者：
MCNEAL, DR
通讯作者：
MCNEAL, DR
影响因子：
3.8
作者：
VANDENHONERT, C;MORTIMER, JT
通讯作者：
MORTIMER, JT
影响因子：
4.1
作者：
Ondo, William G.;Meilak, Catherine;Vuong, Kevin D.
通讯作者：
Vuong, Kevin D.
影响因子：
4.6
作者：
STRUIJK, JJ;HOLSHEIMER, J;BOOM, HBK
通讯作者：
BOOM, HBK
影响因子：
4.7
作者：
Butson, Christopher R.;McIntyre, Cameron C.
通讯作者：
McIntyre, Cameron C.