Maternal gestational weight gain and offspring risk for childhood overweight or obesity.
Maternal gestational weight gain and offspring risk for childhood overweight or obesity.
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DOI：
10.1016/j.ajog.2014.02.030
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发表时间：
2014-09
影响因子：
9.8
通讯作者：
Hedderson, Monique M.
中科院分区：
文献类型：
--
作者：
Sridhar, Sneha B.;Darbinian, Jeanne;Ehrlich, Samantha F.;Markman, Margot A.;Gunderson, Erica P.;Ferrara, Assiamira;Hedderson, Monique M.
该研究的目的是根据2009年医学研究所（IOM）的建议，评估妊娠期体重增加与2-5岁时后代超重/肥胖之间的相关性。这是一项前瞻性队列研究，纳入了4145名完成健康调查（2007-2009年）并随后在Kaiser Permanente北方加州分娩单胎（2007-2010年）的女性。儿童期超重/肥胖定义为体重指数（BMI）z评分为疾病控制和预防中心儿童生长标准的第85百分位数或更高。根据2009年IOM的建议，对体重增加进行了分类。使用逻辑回归;符合IOM的建议是参考。超过IOM的建议与超重/肥胖儿童的几率增加46%有关（优势比[OR]，1.46; 95%置信区间[CI]，1.17-1.83），校正母亲孕前BMI、人种/种族、分娩年龄、教育、儿童年龄、出生体重、分娩孕周、妊娠期糖尿病、产次、婴儿性别后，总代谢当量和饮食模式。体重低于IOM建议值的女性儿童期超重/肥胖的OR（95%CI）为1.23（0.88-1.71）。在孕前BMI正常的女性中，超出IOM建议的体重增加与儿童肥胖之间的关联更强（OR，1.63; 95%CI，1.03-2.57）（下图）; OR，1.79; 95%CI，1.32-2.43）（超出）。在IOM建议范围之外的体重增加与儿童期超重/肥胖的几率增加相关，独立于几个潜在的混杂因素和中介因素。在体重正常的女性中，体重增加对儿童期超重/肥胖的影响更大，这表明这种影响可能与肥胖的遗传预测因素无关。
The objective of the study was to evaluate the association between gestational weight gain, per the 2009 Institute of Medicine (IOM) recommendations, and offspring overweight/obesity at 2–5 years of age. This was a prospective cohort study of 4145 women who completed a health survey (2007–2009) and subsequently delivered a singleton at Kaiser Permanente Northern California (2007–2010). Childhood overweight/obesity was defined as a body mass index (BMI) z-score of the 85th percentile or greater of the Centers for Disease Control and Prevention child growth standards. Gestational weight gain was categorized according to the 2009 IOM recommendations. Logistic regression was used; meeting the IOM recommendations was the referent. Exceeding the IOM recommendations was associated with a 46% increase in odds of having an overweight/obese child (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.17–1.83), after adjusting for maternal prepregnancy BMI, race/ethnicity, age at delivery, education, child age, birthweight, gestational age at delivery, gestational diabetes, parity, infant sex, total metabolic equivalents, and dietary pattern. The OR (95% CI) for childhood overweight/obesity among women gaining below the IOM recommendations was 1.23 (0.88–1.71). The associations between gaining outside the IOM recommendations and childhood obesity were stronger among women with a normal prepregnancy BMI (OR, 1.63; 95% CI, 1.03–2.57) (below); OR, 1.79; 95% CI, 1.32–2.43) (exceeded). Gestational weight gain outside the IOM recommendations is associated with increased odds of childhood overweight/obesity, independent of several potential confounders and mediators. Gestational weight gain had a greater impact on childhood overweight/obesity among normal-weight women, suggesting that the effect may be independent of genetic predictors of obesity.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
3.7
作者：
Morandi A;Meyre D;Lobbens S;Kleinman K;Kaakinen M;Rifas-Shiman SL;Vatin V;Gaget S;Pouta A;Hartikainen AL;Laitinen J;Ruokonen A;Das S;Khan AA;Elliott P;Maffeis C;Gillman MW;Järvelin MR;Froguel P
通讯作者：
Froguel P
DOI：
10.1111/j.1463-1326.2011.01489.x
发表时间：
2012-03
期刊：
Diabetes, obesity & metabolism
影响因子：
--
作者：
Herring SJ;Rose MZ;Skouteris H;Oken E
通讯作者：
Oken E
影响因子：
4.3
作者：
Rudra, Carole B.;Frederick, Ihunnaya O.;Williams, Michelle A.
通讯作者：
Williams, Michelle A.
影响因子：
4.9
作者：
Fogelholm, M;Nuutinen, O;Säätelä, T
通讯作者：
Säätelä, T