Advances in gadolinium-based MRI contrast agent designs for monitoring biological processes in vivo.
Advances in gadolinium-based MRI contrast agent designs for monitoring biological processes in vivo.
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DOI：
10.1016/j.cbpa.2018.04.006
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发表时间：
2018-08
影响因子：
7.8
通讯作者：
Sherry AD
中科院分区：
文献类型：
--
作者：
Lux J;Sherry AD
30年来广泛用于诊断性MRI检查的钆基造影剂都是小分子造影剂，进入组织的所有细胞外间隙，不提供任何特定的生物学信息。尽管在过去的20年里已经提出了许多“反应剂”的设计，但目前还没有发现在临床诊断医学中的应用。本文综述了最近采取的一些方法，以提高这些钆基剂的敏感性，使其靶向特定的组织成分，并建立新的系统，用于监测特定的生物过程。钆基MRI造影剂已广泛应用于临床医学约30年。用于靶向特定生物结构或监测生物过程的下一代设计已在体内得到证实。这些试剂的灵敏度已经通过优化其水交换速率和分子运动而得到改善，并且通过纳米颗粒的信号放大开始显示出希望。本文总结了最新设计的趋势。
The gadolinium-based contrast agents widely used in diagnostic MRI exams for 30 years are all small molecule agents enter all extracellular space in tissues without providing any specific biological information. Although many “responsive agent” designs have been presented over the past 20 years or so, none have found use in clinical diagnostic medicine at this point. This review summarizes some recent approaches taken to enhance the sensitivity of such gadolinium-based agents, to target them to specific tissue components, and to create new systems for monitoring specific biological processes. Gadolinium-based MRI contrast agents have been widely used in clinical medicine for ~30 years. Next generation designs for targeting specific biological structures or monitoring biological processes have been demonstrated in vivo. The sensitivity of such agents has been improved by optimizing their water exchange rates and molecular motions and signal amplification via nanoparticles is beginning to show promise. Trends in the latest designs are summarized in this article.
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DOI：
10.1039/c3tb21104e
发表时间：
2013-12-14
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Lux J;Chan M;Elst LV;Schopf E;Mahmoud E;Laurent S;Almutairi A
通讯作者：
Almutairi A
影响因子：
15
作者：
Floyd WC 3rd;Klemm PJ;Smiles DE;Kohlgruber AC;Pierre VC;Mynar JL;Fréchet JM;Raymond KN
通讯作者：
Raymond KN
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
4.8
作者：
Lauffer, RB;Parmelee, DJ;Walovitch, RC
通讯作者：
Walovitch, RC
影响因子：
6.2
作者：
Chan, Minnie;Lux, Jacques;Almutairi, Adah
通讯作者：
Almutairi, Adah