Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.

Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.
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DOI:
10.1038/nchembio.1178
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发表时间:
2013-04
影响因子:
14.8
通讯作者:
Chory, Joanne
Chory, Joanne
中科院分区:
生物学1区
文献类型:
--
作者:
Zheng, Zuyu;Guo, Yongxia;Novak, Ondrej;Dai, Xinhua;Zhao, Yunde;Ljung, Karin;Noel, Joseph P.;Chory, Joanne

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我们鉴定了一种依赖于磷酸吡哆醛(PLP)的转氨酶VAS1,它的功能丧失会同时增加植物激素生长素和乙烯前体1-氨基环丙烷-1-羧酸(ACC)的水平。VAS1以乙烯生物合成中间体蛋氨酸为氨基供体,以生长素生物合成中间体吲哚-3-丙酮酸(3-IPA)为氨基受体,合成L-色氨酸和2-氧代-4-甲硫基丁酸。我们的数据表明,VAS1在协调这两种重要荷尔蒙的水平方面起着关键作用。
We identify an Arabidopsis pyridoxal-phosphate (PLP)-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases levels of the phytohormone auxin and the ethylene precursor 1-aminocyclopropane-1-carboxylate (ACC). VAS1 uses the ethylene biosynthetic intermediate Met as an amino donor and the auxin biosynthetic intermediate, indole-3-pyruvic acid (3-IPA) as an amino acceptor to produce L-Trp and 2-oxo-4-methylthiobutyric acid (KMBA). Our data indicate that VAS1 serves key roles in coordinating the levels of these two vital hormones.
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