Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability.
Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability.
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DOI：
10.1186/1471-2407-14-991
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发表时间：
2014-12-22
期刊：
影响因子：
3.8
通讯作者：
Gerotziafas GT
中科院分区：
文献类型：
--
作者：
Chaari M;Ayadi I;Rousseau A;Lefkou E;Van Dreden P;Sidibe F;Ketatni H;Galea V;Khaterchi A;Bouzguenda R;Frikha M;Ghorbal L;Daoud J;Kallel C;Quinn M;Gligorov J;Lotz JP;Hatmi M;Elalamy I;Gerotziafas GT
在乳腺癌患者中，不推荐常规血栓预防，但鼓励个体化风险评估。高凝性生物标志物的纳入可以增加风险评估模型（RAM）的敏感性，以识别VTE风险的患者。为此，我们研究了癌症相关特征对高凝性生物标志物的影响。在62名患有乳腺癌的女性和30名年龄匹配的健康女性的队列中评估用Thrombogramme-Thrombinoscope®评估的凝血酶生成（TG）、用流式细胞术评估的血小板衍生微粒（Pd-MP）水平、用凝血测定法测量的促凝血磷脂依赖性凝血时间（PPL-ct）和D-二聚体。与对照组相比，患者显示出显著更高的TG、Pd-MP、D-二聚体水平和缩短的PPL-ct。PPL-ct与Pd-MP水平呈负相关，97%的患者Pd-MP水平升高。TG和D-二聚体分别在76%和59%的患者中升高。在疾病的任何阶段，与对照组相比，TG显著增加。TG在局部、区域转移和转移期之间差异无统计学意义。局部或区域性癌症患者亚组之间Pd-MP或Pd-MP/PS+无显著差异。转移性疾病患者的Pd-MP和Pd-MP/PS+水平显著高于区域分期患者。D-二聚体在转移期患者中升高。自诊断后不到6个月接受化疗的患者中，TG显著高于间隔> 6个月接受化疗的患者。转移性疾病患者的Pd-MP和D-二聚体水平显著高于非转移性疾病患者。在乳腺癌患者的阶段，从诊断和化疗的管理经过的时间是细胞和血浆高凝状态的决定因素。Pd-MP的水平和促凝血活性与癌症的生物活性和总体负担相互关联。TG反映了乳腺癌和化疗在癌症诊断初期的促凝血特性。因此，在RAM中加权掺入细胞和血浆高凝性生物标志物可能会提高其对VTE的预测价值。
In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of risk assessment models (RAM) to identify patients at VTE risk. To this aim we investigated the impact of cancer-related characteristics on hypercoagulability biomarkers. Thrombin generation (TG) assessed with the Thrombogramme-Thrombinoscope®, levels of platelet derived microparticles (Pd-MP) assessed with flow cytometry, procoagulant phospholid dependent clotting time (PPL-ct) measured with a clotting assay and D-Dimers (were assessed in a cohort of 62 women with breast cancer and in 30 age matched healthy women. Patients showed significantly higher TG, Pd-MP, D-Dimers levels and shortened PPL-ct compared to the controls. The PPL-ct was inversely correlated with the levels of Pd-MP, which were increased in 97% of patients. TG and D-Dimers were increased in 76% and 59% of patients respectively. In any stage of the disease TG was significantly increased as compared to the controls. There was no significant difference of TG in patients with local, regional of metastatic stage. There was no significant difference in Pd-MP or Pd-MP/PS+ between the subgroups of patients with local or regional stage of cancer. Patients with metastatic disease had significantly higher levels of Pd-MP and Pd-MP/PS+ compared to those with regional stage. The D-Dimers increased in patients with metastatic stage. In patients on chemotherapy with less than 6 months since diagnosis TG was significantly higher compared to those on chemotherapy who diagnosed in interval > 6 months. Patients with metastatic disease had significantly higher levels of Pd-MP and D-Dimers compared to those with non-metastatic disease. In breast cancer patients the stage, the time elapsed since the diagnosis and the administration of chemotherapy are determinants of cellular and plasma hypercoagulability. The levels and the procoagulant activity of Pd-MP are interconnected with the biological activity and the overall burden of cancer. TG reflects the procoagulant properties of both breast cancer and chemotherapy in the initial period of cancer diagnosis. Thus the weighted incorporation of the biomarkers of cellular and plasma hypercoagulabilty in RAM for VTE might improve their predictive value.
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影响因子：
45.3
作者：
Chew, Helen K.;Wun, Theodore;White, Richard H.
通讯作者：
White, Richard H.
影响因子：
--
作者：
Heit, JA;Mohr, DN;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
7.5
作者：
Butenas, Saulius;Orfeo, Thomas;Mann, Kenneth G.
通讯作者：
Mann, Kenneth G.
DOI：
10.3324/haematol.2011.054718
发表时间：
2012-08-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Ay, Cihan;Dunkler, Daniela;Pabinger, Ingrid
通讯作者：
Pabinger, Ingrid
影响因子：
6.7
作者：
Nurden, Alan T.
通讯作者：
Nurden, Alan T.