Genetic variance in the adiponutrin gene family and childhood obesity.
Genetic variance in the adiponutrin gene family and childhood obesity.
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DOI：
10.1371/journal.pone.0005327
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Ridderstråle M
中科院分区：
文献类型：
--
作者：
Johansson LE;Johansson LM;Danielsson P;Norgren S;Johansson S;Marcus C;Ridderstråle M
脂联素基因家族由5个基因(PNPLA1-5)组成，编码同时具有脂解和成脂特性的蛋白质。PNPLA3此前曾被认为与成人肥胖有关。在这里，我们调查了这些基因的遗传变异与儿童和青少年肥胖之间的可能联系。在一项儿童和青少年肥胖病例对照研究中，利用Sequenom平台选择了脂联素基因家族的五个基因的多态并进行了基因分型。经年龄和性别调整后，PNPLA1基因有6个变异与肥胖有关(rs9380559、rs12212459、rs1467912、rs4713951、rs10947600和rs12199580，p<；0.05)。在对年龄和性别进行调整之前，PNPLA3的三个变异与肥胖有关(rs139051，rs12483959，rs2072907，p>；0.05)。当分析这些SNP与表型的关系时，发现PNPLA3基因中的两个SNP与胰岛素敏感性有关(rs12483959：β = −0.053，p = 0.016；rs2072907：β = −0.049，p = 0.024)。未发现PNPLA2、PNPLA4和PNPLA5之间存在关联。脂联素基因家族的遗传变异似乎并不是儿童和青少年肥胖的主要原因。PNPLA1对肥胖的影响不大，PNPLA3对胰岛素敏感性的影响不大。然而，这些数据需要在其他队列和种族群体中得到证实。
The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: β = −0.053, p = 0.016, and rs2072907: β = −0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.
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影响因子：
3.5
作者：
Qi, L;Shen, H;Ordovas, JM
通讯作者：
Ordovas, JM
影响因子：
7.7
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Johansson, LE;Hoffstedt, J;Ridderstråle, M
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Ridderstråle, M
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通讯作者：
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作者：
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