Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction.
Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction.
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DOI：
10.3389/fnbeh.2012.00063
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发表时间：
2012
影响因子：
3
通讯作者：
Zernig G
中科院分区：
文献类型：
--
作者：
El Rawas R;Klement S;Kummer KK;Fritz M;Dechant G;Saria A;Zernig G
积极的社会互动可以在将药物依赖者的偏好从与毒品有关的活动中转移出来方面发挥重要作用。我们之前已经证明，当大鼠同时将可卡因与一个隔室和另一个隔间进行社交互动时，对可卡因15 mg/kg剂量的条件性位置偏好(CPP)和四次15分钟的社交互动的CPP同样强烈。本研究的目的是研究可卡因CPP或社会交互CPP获得/表达后与奖赏回路相关的脑区的差异激活。我们的发现表明，可卡因CPP和社交CPP激活了几乎相同的大脑区域。但在可卡因CPP后，颗粒岛叶皮质和无颗粒岛叶皮质的背侧部分更活跃，而社会交互CPP后，初级皮质和伏核核心区的激活更多。这些结果表明，在药物条件化学习后，岛叶皮质似乎被有效地激活，而前额叶皮质-伏隔核核心投射的激活似乎优先参与对非药物刺激的条件反射，如社会互动。
Positive social interaction could play an essential role in switching the preference of the substance dependent individual away from drug related activities. We have previously shown that conditioned place preference (CPP) for cocaine at the dose of 15 mg/kg and CPP for four 15-min episodes of social interaction were equally strong when rats were concurrently conditioned for place preference by pairing cocaine with one compartment and social interaction with the other. The aim of the present study was to investigate the differential activation of brain regions related to the reward circuitry after acquisition/expression of cocaine CPP or social interaction CPP. Our findings indicate that cocaine CPP and social interaction CPP activated almost the same brain regions. However, the granular insular cortex and the dorsal part of the agranular insular cortex were more activated after cocaine CPP, whereas the prelimbic cortex and the core subregion of the nucleus accumbens were more activated after social interaction CPP. These results suggest that the insular cortex appears to be potently activated after drug conditioning learning while activation of the prelimbic cortex—nucleus accumbens core projection seems to be preferentially involved in the conditioning to non-drug stimuli such as social interaction.
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