Anterior-posterior patterning in early development: three strategies.

Anterior-posterior patterning in early development: three strategies.
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DOI:
10.1002/wdev.25
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发表时间:
2012-03
期刊:
Wiley interdisciplinary reviews. Developmental biology
影响因子:
--
通讯作者:
Martin BL
Martin BL
中科院分区:
其他
文献类型:
--
作者:
Kimelman D;Martin BL

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前-后(AP)轴是最古老的胚胎轴,存在于大多数后生动物中。不同的动物使用各种各样的机制在早期胚胎中创建这个轴。在这里,我们专注于三种动物,包括两种昆虫(果蝇和赤拟谷盗)和一种脊椎动物(斑马鱼),以研究用于形成AP轴的不同策略。虽然果蝇使用转录因子作为形态发生剂在合胞胚盘内形成整个轴,但斑马鱼在细胞化胚胎中使用信号因子,在一天的过程中逐渐形成AP轴。Tribolium使用一种中间策略,与果蝇和斑马鱼都有共同之处。我们讨论了用于创建AP轴的特定分子机制,并确定保守的功能。
The Anterior-Posterior (AP) axis is the most ancient of the embryonic axes, and exists in most metazoans. Different animals use a wide variety of mechanisms to create this axis in the early embryo. Here we focus on three animals, including two insects (Drosophila and Tribolium) and a vertebrate (zebrafish) to examine different strategies used to form the AP axis. While Drosophila forms the entire axis within a syncytial blastoderm using transcription factors as morphogens, zebrafish uses signaling factors in a cellularized embryo, progressively forming the AP axis over the course of a day. Tribolium uses an intermediate strategy that has commonalities with both Drosophila and zebrafish. We discuss the specific molecular mechanisms used to create the AP axis, and identify conserved features.
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