PRP Augmentation for ACL Reconstruction.

PRP Augmentation for ACL Reconstruction.
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ACL重建的PRP增强。

DOI:
10.1155/2015/371746
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发表时间:
2015
影响因子:
--
通讯作者:
Marcacci M
Marcacci M
中科院分区:
生物学3区
文献类型:
--
作者:
Andriolo L;Di Matteo B;Kon E;Filardo G;Venieri G;Marcacci M

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目前的研究正在探索促进组织愈合的新方法,以加快前交叉韧带(ACL)重建手术的恢复时间,降低失败的风险。生物强化是应用最多的方法之一,尤其是富含血小板血浆(PRP)的应用。本文旨在系统综述PRP作为生物增强剂在前交叉韧带重建手术中应用的临床前和临床研究文献。本综述包括32项研究。对临床前证据的分析表明,PRP能够在组织学和生物力学性能方面改善肌腱移植物的愈合潜力。看看现有的临床证据,结果并不是一成不变的。PRP的应用被证明是一种安全的方法,而且有证据表明,在使用髌腱重建前交叉韧带的情况下,PRP可以促进供区的愈合,并随着时间的推移对移植物的成熟有积极的促进作用,而大多数文献在骨隧道/移植物区域整合方面没有显示出有利的效果。此外,在短期评估中,PRP增强并没有提供更好的功能结果。
Current research is investigating new methods to enhance tissue healing to speed up recovery time and decrease the risk of failure in Anterior Cruciate Ligament (ACL) reconstructive surgery. Biological augmentation is one of the most exploited strategies, in particular the application of Platelet Rich Plasma (PRP). Aim of the present paper is to systematically review all the preclinical and clinical papers dealing with the application of PRP as a biological enhancer during ACL reconstructive surgery. Thirty-two studies were included in the present review. The analysis of the preclinical evidence revealed that PRP was able to improve the healing potential of the tendinous graft both in terms of histological and biomechanical performance. Looking at the available clinical evidence, results were not univocal. PRP administration proved to be a safe procedure and there were some evidences that it could favor the donor site healing in case of ACL reconstruction with patellar tendon graft and positively contribute to graft maturation over time, whereas the majority of the papers did not show beneficial effects in terms of bony tunnels/graft area integration. Furthermore, PRP augmentation did not provide superior functional results at short term evaluation.
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