Hippocampal replay of extended experience.
Hippocampal replay of extended experience.
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DOI：
10.1016/j.neuron.2009.07.027
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发表时间：
2009-08-27
期刊：
影响因子：
16.2
通讯作者：
Wilson, Matthew A.
中科院分区：
文献类型：
--
作者：
Davidson, Thomas J.;Kloosterman, Fabian;Wilson, Matthew A.
在探索暂停期间，大鼠海马体中的位置细胞群重新表达与最近的空间体验相对应的放电序列。这种“重放”与涟漪事件同时发生：持续时间短（~ 50-120毫秒），频率高（~200赫兹）的振荡与海马与皮层之间的交流增加有关。在之前的研究中，大鼠探索小环境，并且发现重播被锚定在大鼠的当前位置，并在时间上被压缩，以便在单个涟漪事件中重播整个环境。目前尚不清楚行为序列是否会在海马体中重复播放，或者重复播放的时间有多长。在这里，我们展示了，使用神经解码方法，发射序列对应于在一个大的环境中长时间运行以高保真度重播（在正向和反向顺序），并且这种重播可以在轨道上的远程位置开始。扩展重播以~8 m/s的特征虚拟速度进行，并在纹波事件序列中保持相干。这些结果表明，延长的重播是由较短的子序列链组成的，这可能反映了长时间经验记忆的存储和灵活表达策略。
During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such ‘replay’ co-occurs with ripple events: short-lasting (~50–120 ms), high frequency (~200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats explored small environments, and replay was found to be anchored to the rat’s current location, and compressed in time such that replay of the complete environment occurred during a single ripple event. It is not known whether or how longer behavioral sequences are replayed in the hippocampus. Here we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity (in both forward and reverse order), and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of ~8 m/s, and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience.
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DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
3.1
作者：
Canto CB;Wouterlood FG;Witter MP
通讯作者：
Witter MP
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
3.5
作者：
Foster, David J.;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
16.2
作者：
Isomura, Yoshikazu;Sirota, Anton;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy