Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study.
Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study.
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DOI：
10.1186/s12955-018-0952-5
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发表时间：
2018-06-13
影响因子：
3.6
通讯作者：
Pros-IT CNR study group
中科院分区：
文献类型：
--
作者：
Porreca A;Noale M;Artibani W;Bassi PF;Bertoni F;Bracarda S;Conti GN;Corvò R;Gacci M;Graziotti P;Magrini SM;Mirone V;Montironi R;Muto G;Pecoraro S;Ricardi U;Russi E;Tubaro A;Zagonel V;Crepaldi G;Maggi S;Pros-IT CNR study group
意大利国家研究委员会 (CNR) 前列腺癌监测项目 (Pros-IT CNR) 是一项观察性、前瞻性、持续性、多中心研究，旨在监测被诊断为前列腺癌新病例的意大利男性样本。本研究旨在提供前列腺癌诊断时生活质量的数据。招募了一千七百五名患者。生活质量在诊断癌症时进行评估，并在随后的评估中通过加州大学洛杉矶分校前列腺癌指数 (UCLA-PCI) 和简表健康调查 (SF-12) 进行评估。诊断时，SF-12 身体成分得分较低与年龄较大、肥胖和存在 3 种以上中度/重度合并症有关。心理成分得分较低与年龄较小、存在 3 种以上中度/重度合并症以及 T 得分高于 1 相关。根据 UCLA-PCI，泌尿和肠道功能总体良好。近 5% 的样本报告每天至少使用一块安全垫来控制尿液流失；不到 3% 的人报告因肠道功能而出现中度/重度问题，而性功能则为 26.7% 的中度/重度问题。糖尿病、3+ 中度/重度合并症、T2 或 T3-T4 类别以及格里森评分 8 或更高与诊断时性功能评分较低显着相关。 Pros-IT CNR 研究收集的数据阐明了新诊断的前列腺癌患者的基线状态。对生活质量的全面评估将能够客观地评估不同护理方案的结果。
The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
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影响因子：
2.1
作者：
Gacci, M;Livi, L;Gacci, M
通讯作者：
Gacci, M
影响因子：
3.5
作者：
Singer, MA;Hopman, WM;MacKenzie, TA
通讯作者：
MacKenzie, TA
影响因子：
4.5
作者：
Lane, Athene;Metcalfe, Chris;Donovan, Jenny L.
通讯作者：
Donovan, Jenny L.
影响因子：
1.4
作者：
Krupski, TL;Fink, A;Litwin, MS
通讯作者：
Litwin, MS
影响因子：
28.4
作者：
Global Burden of Disease Cancer Collaboration;Fitzmaurice C;Akinyemiju TF;Al Lami FH;Alam T;Alizadeh-Navaei R;Allen C;Alsharif U;Alvis-Guzman N;Amini E;Anderson BO;Aremu O;Artaman A;Asgedom SW;Assadi R;Atey TM;Avila-Burgos L;Awasthi A;Ba Saleem HO;Barac A;Bennett JR;Bensenor IM;Bhakta N;Brenner H;Cahuana-Hurtado L;Castañeda-Orjuela CA;Catalá-López F;Choi JJ;Christopher DJ;Chung SC;Curado MP;Dandona L;Dandona R;das Neves J;Dey S;Dharmaratne SD;Doku DT;Driscoll TR;Dubey M;Ebrahimi H;Edessa D;El-Khatib Z;Endries AY;Fischer F;Force LM;Foreman KJ;Gebrehiwot SW;Gopalani SV;Grosso G;Gupta R;Gyawali B;Hamadeh RR;Hamidi S;Harvey J;Hassen HY;Hay RJ;Hay SI;Heibati B;Hiluf MK;Horita N;Hosgood HD;Ilesanmi OS;Innos K;Islami F;Jakovljevic MB;Johnson SC;Jonas JB;Kasaeian A;Kassa TD;Khader YS;Khan EA;Khan G;Khang YH;Khosravi MH;Khubchandani J;Kopec JA;Kumar GA;Kutz M;Lad DP;Lafranconi A;Lan Q;Legesse Y;Leigh J;Linn S;Lunevicius R;Majeed A;Malekzadeh R;Malta DC;Mantovani LG;McMahon BJ;Meier T;Melaku YA;Melku M;Memiah P;Mendoza W;Meretoja TJ;Mezgebe HB;Miller TR;Mohammed S;Mokdad AH;Moosazadeh M;Moraga P;Mousavi SM;Nangia V;Nguyen CT;Nong VM;Ogbo FA;Olagunju AT;Pa M;Park EK;Patel T;Pereira DM;Pishgar F;Postma MJ;Pourmalek F;Qorbani M;Rafay A;Rawaf S;Rawaf DL;Roshandel G;Safiri S;Salimzadeh H;Sanabria JR;Santric Milicevic MM;Sartorius B;Satpathy M;Sepanlou SG;Shackelford KA;Shaikh MA;Sharif-Alhoseini M;She J;Shin MJ;Shiue I;Shrime MG;Sinke AH;Sisay M;Sligar A;Sufiyan MB;Sykes BL;Tabarés-Seisdedos R;Tessema GA;Topor-Madry R;Tran TT;Tran BX;Ukwaja KN;Vlassov VV;Vollset SE;Weiderpass E;Williams HC;Yimer NB;Yonemoto N;Younis MZ;Murray CJL;Naghavi M
通讯作者：
Naghavi M